Abstract
The aim of this study was to determine the immunoreactivity of normal small bronchial, bronchiolar, respiratory bronchiolar, and interalveolar epithelium using antibodies to six mucins: MUC1, MUC2, MUC4, MUC5AC, MUC5B, and MUC6. The large, gel-forming secreted mucins MUC2, MUC5AC, and MUC5B were widely expressed in the lower respiratory tract. The results of this study demonstrate that these secreted mucins form a gel to cover and protect the mucosal surface in the lower respiratory tract of pigs.
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Acknowledgements
This research was supported by the Preparation Research Fund for WCU from Research Affairs of Seoul National University, contract research funds of the Research Institute for Veterinary Science (RIVS) from the College of Veterinary Medicine, and by the Brain Korea 21 Program for Veterinary Science in the Republic of Korea. This research was also supported by the Brain Korea 21 Program for Veterinary Science and the Korea Research Foundation Grant (KRF-2006-J02902-2) in the Republic of Korea.
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None of the authors has any financial or personal relationships that could inappropriately influence or bias the content of the paper.
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Chung Hyun Kim and Kichan Lee made an equal contribution to this work, they are co-first authors.
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Kim, C.H., Lee, K., Han, K. et al. Expression of mucins on the mucosal surface of lungs of 4-week-old pigs. Vet Res Commun 35, 255–260 (2011). https://doi.org/10.1007/s11259-011-9465-y
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DOI: https://doi.org/10.1007/s11259-011-9465-y