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NMR elucidation of novel SQ109 derivatives

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Abstract

The NMR elucidation of five novel SQ109 analogues including SQ109 is reported herein. These derivatives were synthesized as potential anti-tuberculosis candidates. One-dimensional NMR (1H and 13C) techniques show a series of overlapping signals from the methine and methylene groups of these compounds, thereby making it extremely difficult to assign all NMR signals. Two-dimensional (2D) NMR techniques were instrumental in overcoming these challenges. This paper appears to be a rare report on the complete structure elucidation of mono-substituted adamantane moieties.

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Acknowledgment

This study was supported by Grants from the National Research Foundation, GUN 2073251, Aspen Pharmacare and the University of KwaZulu-Natal.

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Authors and Affiliations

  1. School of Chemistry, University of KwaZulu-Natal, Durban, South Africa

    Oluseye K. Onajole, Glenn E. M. Maguire & Hendrik G. Kruger

  2. School of Biochemistry, Genetics and Microbiology, University of KwaZulu-Natal, Durban, South Africa

    Patrick Govender

  3. School of Pharmacy and Pharmacology, University of KwaZulu-Natal, Durban, South Africa

    Thavendran Govender

Authors
  1. Oluseye K. Onajole
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  2. Patrick Govender
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  3. Thavendran Govender
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  4. Glenn E. M. Maguire
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  5. Hendrik G. Kruger
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Corresponding author

Correspondence to Hendrik G. Kruger.

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Onajole, O.K., Govender, P., Govender, T. et al. NMR elucidation of novel SQ109 derivatives. Struct Chem 21, 1203–1209 (2010). https://doi.org/10.1007/s11224-010-9661-3

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  • DOI: https://doi.org/10.1007/s11224-010-9661-3

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