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Synthesis and chemical transformations of 3-acetyl-4-hydroxyquinolin-2(1H)-one and its N-substituted derivatives: bird’s eye view

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Abstract

The chemistry of 3-acetyl-4-hydroxyquinolin-2(1H)-ones has attracted increased attention in both synthetic organic and medicinal chemistry, as numerous advancements in the use of this family of important compounds seems to be of considerable value. This account summarizes the results from the literature focusing on synthesis of 3-acetyl-4-hydroxyquinolin-2(1H)-ones as well as their reactions are also discussed.

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Authors and Affiliations

  1. Egyptian Petroleum Research Institute, P.O. 11727, Nasr City, Cairo, Egypt

    Moaz M. Abdou & Mahmoud Fathy

  2. Department of Chemistry, University of Liverpool, Liverpool, L69 7ZD, UK

    Moaz M. Abdou

  3. Department of Chemistry, Xi’an Jiaotong Liverpool University, Suzhou, 215123, Jiangsu, People’s Republic of China

    Moaz M. Abdou, Ruba Kellow & Eric Amigues

  4. Department of Chemistry, Gazi University, 06500, Ankara, Turkey

    Zeynel Seferoğlu

  5. Department of Chemistry, Faculty of Science, Tokyo University of Science, Tokyo, 162-8601, Japan

    Takashiro Akitsu

  6. Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, Gifu, 501-1193, Japan

    Mamoru Koketsu

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  1. Moaz M. Abdou
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Abdou, M.M., Seferoğlu, Z., Fathy, M. et al. Synthesis and chemical transformations of 3-acetyl-4-hydroxyquinolin-2(1H)-one and its N-substituted derivatives: bird’s eye view. Res Chem Intermed 45, 919–934 (2019). https://doi.org/10.1007/s11164-018-3652-1

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