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Using latent trajectory analysis of residuals to detect response shift in general health among patients with multiple sclerosis article

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An Erratum to this article was published on 21 December 2011

Abstract

Background and objective

Individuals experiencing a change in health may experience a response shift that may attenuate HRQoL change estimates. The objective of this study was to estimate the proportion of individuals with multiple sclerosis (MS) who experienced a response shift as detected by the Latent Trajectory of Residuals approach.

Methods

Participants in the NARCOMS Registry were included if they responded to the general health (GH) question of the SF-12 in at least 3 surveys. Linear growth modeling was used to identify predictors of self-reported GH, and the residuals from this model were used to determine group-based trajectories. Dual trajectories of GH and a measure of disability (PDSS) were used to examine convergence in change patterns over time.

Results

A total of 1,566 individuals were included in this study. The predictive GH model explained 55% of the variance; 99.7% of subjects did not experience a response shift as indicated by flat trajectories, and 0.3% lowered their rating of health as compared to predicted indicating a potential response shift. Among 13% of subjects with flat trajectories of PDDS, 5% had GH decreasing most strongly showing some discordance between symptoms and GH.

Conclusions

A lower percentage of individuals experienced response shift than previous research on smaller samples. These results may indicate the true absence of response shift, or may be limited by using a categorical outcome of GH, and GH predictors that may have also been amenable to response shift, which decreases the appropriateness of using the LTA approach. Future work will include the use of growth curve latent class analyses to assess response shift.

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Acknowledgments

This work is supported in part by the Fonds de la Recherche en Santé du Québec to Dr. Ahmed, and by a Visiting Scientist Fellowship from the Consortium of Multiple Sclerosis Centers to Dr. Schwartz.

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Authors and Affiliations

  1. Faculty of Medicine, School of Physical and Occupational Therapy, McGill University, 3654 Prom Sir-William-Osler, Montreal, QC, H3G 1Y5, Canada

    Sara Ahmed, Nancy Mayo & Ayse Kuspinar

  2. Division of Clinical Epidemiology, McGill University Health Center, Montreal, Canada

    Sara Ahmed, Nancy Mayo & Susan Scott

  3. DeltaQuest Foundation, Inc., Concord, MA, USA

    Carolyn Schwartz

  4. Departments of Medicine and Orthopaedic Surgery, Tufts University School of Medicine, Boston, MA, USA

    Carolyn Schwartz

Authors
  1. Sara Ahmed
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  2. Nancy Mayo
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  3. Susan Scott
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  4. Ayse Kuspinar
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  5. Carolyn Schwartz
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Corresponding author

Correspondence to Sara Ahmed.

Additional information

An erratum to this article can be found at http://dx.doi.org/10.1007/s11136-011-0093-3

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Ahmed, S., Mayo, N., Scott, S. et al. Using latent trajectory analysis of residuals to detect response shift in general health among patients with multiple sclerosis article. Qual Life Res 20, 1555–1560 (2011). https://doi.org/10.1007/s11136-011-0005-6

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