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Influence of Red Pepper Spice and Turmeric on Inflammation and Oxidative Stress Biomarkers in Overweight Females: A Metabolomics Approach

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Abstract

Red pepper spice (RP) and turmeric (TM) are used as flavorings in foods and for medicinal purposes. Utilizing a randomized, doubled-blinded, placebo-controlled, crossover design (2-week washout), 4-week supplementation with RP (1 g/d) or TM (2.8 g/d) was tested for influences on inflammation and oxidative stress in 62 overweight/obese (body mass index ≥ 27 kg/m2) females (40–75 years) with systemic inflammation (C-reactive protein, CRP ≥ 2 mg/l). Overnight, fasted blood samples were collected pre- and post-supplementation, and analyzed for oxidative stress (F2-isoprostanes, oxidized low density lipoprotein), inflammation (CRP and seven inflammatory cytokines), and metabolic profiles using gas chromatography–mass spectrometry with multivariate partial least square discriminant analysis (PLS-DA). Pre- to post-supplementation measures of inflammation and oxidative stress for both RP and TM did not differ when compared to placebo (all interaction effects, P > 0.05), and global metabolic difference scores calculated through PLS-DA were non-significant (both spices, Q2Y < 0.40). These data indicate that 4-week supplementation with RP or TM at culinary levels does not alter oxidative stress or inflammation in overweight/obese females with systemic inflammation, or cause a significant shift in the global metabolic profile.

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Abbreviations

AIx@75:

Augmentation index normalized for a heart rate of 75 beats/min

ANOVA:

Analysis of variance

BMI:

Body mass index

CRP:

C-reactive protein

CV:

Coefficient of variance

GC-MS:

Gas chromatography mass spectrometry

IL:

Interleukin

IFNγ:

Interferon gamma

LDL:

Low-density lipoprotein

PCA:

Principal component analysis

PLS-DA:

Partial least square discriminant analysis

RP:

Red pepper

TM:

Turmeric

TNFα:

Tumor necrosis factor alpha

TRPV1:

Transient potential receptor vanilloid 1

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Funding

McCormick Science Institute

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Authors and Affiliations

  1. Human Performance Lab, North Carolina Research Campus, Appalachian State University, Kannapolis, NC, 28081, USA

    David C. Nieman, Lynn Cialdella-Kam, Amy M. Knab & R. Andrew Shanely

  2. North Carolina Research Campus, 600 Laureate Way, Kannapolis, NC, 28081, USA

    David C. Nieman

Authors
  1. David C. Nieman
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  2. Lynn Cialdella-Kam
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  3. Amy M. Knab
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  4. R. Andrew Shanely
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Correspondence to David C. Nieman.

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Nieman, D.C., Cialdella-Kam, L., Knab, A.M. et al. Influence of Red Pepper Spice and Turmeric on Inflammation and Oxidative Stress Biomarkers in Overweight Females: A Metabolomics Approach. Plant Foods Hum Nutr 67, 415–421 (2012). https://doi.org/10.1007/s11130-012-0325-x

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  • DOI: https://doi.org/10.1007/s11130-012-0325-x

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