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Alteration in NMDA Receptor Mediated Glutamatergic Neurotransmission in the Hippocampus During Senescence

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Abstract

Glutamate is the primary excitatory neurotransmitter in neurons and glia. N-methyl-d-aspartate (NMDA), α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), and kainate receptors are major ionotropic glutamate receptors. Glutamatergic neurotransmission is strongly linked with Ca2+ homeostasis. Research has provided ample evidence that brain aging is associated with altered glutamatergic neurotransmission and Ca2+ dysregulation. Much of the work has focused on the hippocampus, a brain region critically involved in learning and memory, which is particularly susceptible to dysfunction during senescence. The current review examines Ca2+ regulation with a focus on the NMDA receptors in the hippocampus. Integrating the knowledge of the complexity of age-related alterations in Ca2+ homeostasis and NMDA receptor-mediated glutamatergic neurotransmission will positively shape the development of highly effective therapeutics to treat brain disorders including cognitive impairment.

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Fig. 1
Fig. 2

Reproduced with permission from Kumar and Foster [55]. (Color figure online)

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Acknowledgements

Supported by National Institute of Aging Grants R37AG036800, RO1049711, RO1037984, and RO1052258 and the Evelyn F. McKnight Brain Research Foundation. This work was partially supported by the University of Florida Claude D. Pepper Older Americans Independence Center (P30-AG028740).

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  1. Department of Neuroscience, McKnight Brain Institute, University of Florida, PO Box 100244, Gainesville, FL, 32610-0244, USA

    Ashok Kumar & Thomas C. Foster

  2. Genetics and Genomics Program, University of Florida, Gainesville, FL, 32611, USA

    Thomas C. Foster

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  1. Ashok Kumar
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Correspondence to Ashok Kumar or Thomas C. Foster.

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Special Issue: In honor of Eli Michaelis.

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Kumar, A., Foster, T.C. Alteration in NMDA Receptor Mediated Glutamatergic Neurotransmission in the Hippocampus During Senescence. Neurochem Res 44, 38–48 (2019). https://doi.org/10.1007/s11064-018-2634-4

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  • DOI: https://doi.org/10.1007/s11064-018-2634-4

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