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Oxidative Stress and S100B Protein in Cirrhotic Children

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Abstract

Cirrhosis represents the terminal stage of a number of chronic liver diseases. Consequences include accumulation of toxic metabolic wastes, reduced synthesis of key proteins, increased portal venous pressure, and portosystemic shunting. We conducted a case-control study to assess the serum levels of S100B protein and parameters of oxidative stress, superoxide dismutase (SOD), catalase (CAT) and oxidative stress measured by the thiobarbituric acid method (TBARS), in a group of 14 pediatric patients with cirrhosis. No differences were found between groups in S100B protein levels. SOD activity and TBARS levels were higher; and CAT activity was lower in the cirrhotic group. A negative correlation between S100B and TBARS in the case group was found (r = −0.815, p = 0.001). Conclusions: This study didn’t indicate a possible role of S100B serum levels as marker of brain damage in cirrhotic children but suggest a possible relation between astrocyte function and oxidative damage in cirrhotic children.

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Acknowledgments

The authors thank CAPES and FIPE for financial support.

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Authors and Affiliations

  1. Laboratório de Psiquiatria Experimental, Hospital de Clínicas de Porto Alegre e Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil

    Luciana Ribeiro & Flávio Kapczinski

  2. Instituto de Biotecnologia da Universidade de Caxias do Sul, Caxias do Sul, Brasil

    Ana Cristina Andreazza & Mirian Salvador

  3. Unidade de Gastroenterologia Pediátrica, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brasil

    Themis Reverbel da Silveira & Sandra Vieira

  4. Serviço de Neurologia, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brasil

    Daniel Bocchese Nora

  5. Instituto de Psicologia, Departamento de Psicologia do Desenvolvimento, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil

    Cleonice Bosa & Francesca Di Napoli

  6. Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil

    Débora Vigevani Schaf, Diogo Onofre Souza & Luis Valmor Cruz Portela

  7. 1580 NW 10th Avenue, Batchelors Children‘s Research Institute, 6th floor, Miami, FL, 33136, USA

    Luciana Ribeiro

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  1. Luciana Ribeiro
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  2. Ana Cristina Andreazza
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  3. Mirian Salvador
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  4. Themis Reverbel da Silveira
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  5. Sandra Vieira
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  6. Daniel Bocchese Nora
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  8. Francesca Di Napoli
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  9. Débora Vigevani Schaf
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  10. Diogo Onofre Souza
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  11. Luis Valmor Cruz Portela
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  12. Flávio Kapczinski
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Corresponding author

Correspondence to Luciana Ribeiro.

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Ribeiro, L., Andreazza, A.C., Salvador, M. et al. Oxidative Stress and S100B Protein in Cirrhotic Children . Neurochem Res 32, 1600–1603 (2007). https://doi.org/10.1007/s11064-007-9365-2

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  • DOI: https://doi.org/10.1007/s11064-007-9365-2

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