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Epidemiology for primary brain tumors: a nationwide population-based study

  • Clinical Study
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Journal of Neuro-Oncology Aims and scope Submit manuscript

An Erratum to this article was published on 12 December 2016

Abstract

Primary central nervous system tumors (PCNST) are rare tumors responsible for high mortality and morbidity. Their epidemiology is poorly known, and clinical data are scarcely analyzed at a national level. In this study, we aimed at providing descriptive epidemiological data and incidence rates for all histological subtypes of PCNST according to the WHO classification. We conducted a nationwide population-based study of all newly diagnosed and histologically confirmed PCNST in France, between 2006 and 2011. A total of 57,816 patients were included: male 46.4%, median age at diagnosis 56 years old (range 0–99). For all newly diagnosed PCNST with histological confirmation the crude incidence rate was 15.5/105 per 100,000 person-years. To enable international comparisons, standardized rates were calculated: 14.1/105 (population of reference: USA), 14.5/105 (population of reference: Europe), and 12.0/105 (population of reference: world). 23.4% of samples were cryopreserved. Resection was performed in 79.1% of cases. Results are detailed (incidence rate, sex ratio, median age at diagnosis, number of cryopreserved samples, and type of surgery) for each of the 143 histological subtypes of PCNST, including all rare tumors. For example, incidence rates (population of reference: USA) were 0.018/105 for anaplastic gangliogliomas, 0.054/105 for malignant meningiomas, and 0.036/105 for hemangiopericytomas. Our study is the first to describe incidence rates and epidemiological data for all histological subtypes of PCNST, including rare tumors, at a national level. Its methodology ensures the exhaustiveness of the data collection for histologically-proven cases. Histological population-based studies have many perspectives in the field of clinical epidemiology and research.

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Acknowledgements

The authors wish to acknowledge Dr. Hélène de Forges for reviewing the manuscript and all the doctors and professors who helped and completed the cards for the recording of the PCNST in France: Abbey Toby A., Adam C., Adle-Biassette H., Adreux, Albagnac V., Algros M.P., Amat C., Ansart F., Arbez-Gindre F., Arbion F., Arrivets P., Aubriot Lorton M.H., Auvigne I., Averous G., Pinel-briquel N., Badsi A., Baglin A.C., Baldet P., Barbey C., Bazille C., Bedgedjian I., Bedossa P., Benabidallah S., Benali A., Bergemer Fouquet A.M., Bergouignan M.A., Bernier M., Bertocchi C., Beuvon F., Billotet C., Blechet C., Bondoin L., Bonneau C., Bonyhay G., Bordier, Borrelly C., Bost Bezeaud F., Boudjadi S., Bouvier C., Brambilla E., Branquet D., Bressenot A., Broche C., Brouchet A., Brousse N., Brousset P., Bruniau A., Burel-Vandenbos F., Camparo P., Cahn V., Calvet P., Camo J., Camparo P., Carbonnelle Puscian A., Carloz E., Cassagnau E., Cathelineau D., Caulet S., Caveriviere P., Cazals-Hatem D., Chapon F., Charlotte F., Taranger-Charpin C., Chatelain D., Chenard M.P., Chretien F., Christov C., Clairotte A., Cohen C., Colombat M., Conan V., Conan-Charlet V., Cormier B., Costa K., Costes V., Costes-Charlet N., Coulon A., Couvelard A., Cremades, Croue A., Cruel T., Danjoux M., Darrasse D., Daumas-Duport C., Degano-Valmarx S., Delage Corre M., Delattre C., Delisle M.B., Delsol M., Denoux Y., Deschamps L., Desrousseaux M., Diebold M.D., Donsbeck A.V., Dosda A., Dreux N., Dubost G., Duga I., Dujardin F., Dumollard J.M., Durand L., Duval H., Eimer S., Etchandy M.P., Eyremandi R.P., Fabre B., Fallet C., Felce dachez M., Felix S., Fernandez C., Fetissof F., Feutry C., Fornes P., Figarella-Branger D., Figuccio M., Fornes P., Fouet, Fregeville M., Fromont G., Gaillard F., Gallois S., Gaspard C., Gay G., Gonguet A.M., Gontier M.F., Gonzalez, Goujon J.M., Gray F., Grignon Y., Gros P., Guedj N., Guettier-Bouttier C., Guillou P.J., Guymar S., Gyenes C., Hassoun, Haudebourg J., Heitzmann A., Henin D., Hennequin V., Heymann M.F., Istier L., Jaubert F., Jonas J., Jouan H., Jourdan F., Jouvet A., Justrabo, Kaci R., Kantelip B., Kemeny J.L., Kerdraon O., Kerdraon R., Kermanach P., Khaddage A., Kleinclaus I., Kopp N., Krzisch S., Kujas M., Labrousse F., Lacroix C., Lamant. 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Funding

This work was conducted with the financial support, as Grants, of the French National Cancer Institute (INCa), the Ligue Nationale Contre le Cancer, the Société Française de Neuropathologie (SFNP), the Société Française de Neurochirurgie (SFNC) and the Club of Neuro-Oncologie of the Société Française de Neurochirurgie (CNO-SFNC), the Association des Neuro-Oncologues d’Expression Française (ANOCEF), the Roche Laboratory, the Association pour la Recherche sur les Tumeurs Cérébrales Nord et Sud (ARTC), for the collection, management, analysis and interpretation of the data, and of the SIRIC Montpellier Cancer (Grant “INCa-DGOS-Inserm 6045”) for the design and conduct of the study and for the collection, management, analysis and interpretation of the data.

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Author notes

    Authors and Affiliations

    1. Department of Medical Oncology, Institut Régional du Cancer de Montpellier (ICM)—Val d’Aurelle, 208 rue des Apothicaires, 34298, Montpellier, France

      Amélie Darlix

    2. INSERM U1051, 80 avenue Augustin Fliche, 34091, Montpellier, France

      Amélie Darlix, Hugues Duffau & Luc Bauchet

    3. Department of Epidemiology, French brain tumor database, GNOLR, Registre des Tumeurs de l’Hérault, Institut Régional du Cancer de Montpellier (ICM)—Val d’Aurelle, 208 rue des Apothicaires, 34298, Montpellier, France

      Sonia Zouaoui, Faiza Bessaoud, Hélène Mathieu-Daudé, Brigitte Trétarre & Fabienne Bauchet

    4. Department of Neurosurgery, Gui de Chauliac Hospital, 80 avenue Augustin Fliche, 34090, Montpellier, France

      Sonia Zouaoui, Hugues Duffau & Luc Bauchet

    5. Department of Pathology, Gui de Chauliac Hospital, 80 avenue Augustin Fliche, 34090, Montpellier, France

      Valérie Rigau

    6. Department of Neuropathology and INSERM U911, Timone Hospital, Université de la Méditerranée, 40 rue Ste Baume, 13010, Marseille, France

      Dominique Figarella-Branger

    7. Neuro-oncology Unit, University Hospital, 29 avenue du Maréchal de Lattre de Tassigny, Nancy, France

      Luc Taillandier

    Authors
    1. Amélie Darlix
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    2. Sonia Zouaoui
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    3. Valérie Rigau
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    4. Faiza Bessaoud
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    5. Dominique Figarella-Branger
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    6. Hélène Mathieu-Daudé
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    7. Brigitte Trétarre
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    8. Fabienne Bauchet
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    9. Hugues Duffau
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    10. Luc Taillandier
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    11. Luc Bauchet
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    Corresponding author

    Correspondence to Amélie Darlix.

    Additional information

    The original version of this article was revised: In the first line of Table 1 (line “Tumors of neuroepithelial tissue”), column “Male, n”, the number was corrected to read 14,621.

    Amélie Darlix and Sonia Zouaoui have equally contributed to this work.

    With the participation of the Société Française de Neuropathologie (SFNP), the Société Française de Neurochirurgie (SFNC) and the Club Neuro-Oncologie of the Société Française de Neurochirurgie (CNO-SFNC), and the Association des Neuro-Oncologues d’Expression Française (ANOCEF).

    An erratum to this article is available at http://dx.doi.org/10.1007/s11060-016-2340-5.

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    Darlix, A., Zouaoui, S., Rigau, V. et al. Epidemiology for primary brain tumors: a nationwide population-based study. J Neurooncol 131, 525–546 (2017). https://doi.org/10.1007/s11060-016-2318-3

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    • DOI: https://doi.org/10.1007/s11060-016-2318-3

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