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Radiation-induced adult medulloblastoma: a two-case report and review of the literature

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Abstract

Radiation-induced medulloblastoma is an exceedingly rare phenomenon for which treatment standards have not been established. The literature suggests that these tumors are high grade with aggressive behavior. We report two cases of radiation-induced medulloblastoma which have been treated with full dose re-irradiation with curative intent. In both cases, treatment toxicity and tumor progression proved to be insurmountable obstacles. Further reports are necessary in order to fully characterize this clinical entity so that more effective therapies may be sought.

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Authors and Affiliations

  1. Department of Radiation Oncology, Wake Forest University Health Sciences—Baptist Medical Center, 1 Medical Center Blvd, Winston-Salem, NC, 27103, USA

    Michael D. Chan, Albert Attia, Annette Carter, Kevin P. McMullen & Edward G. Shaw

  2. Department of Neurosurgery, Wake Forest University Health Sciences, Winston-Salem, NC, 27103, USA

    Stephen B. Tatter & Thomas E. Ellis

  3. Department of Internal Medicine (Hematology and Oncology), Wake Forest University Health Sciences, Winston-Salem, NC, 27103, USA

    Glenn Lesser

  4. Department of Radiology, Wake Forest University Health Sciences, Winston-Salem, NC, 27103, USA

    Michael E. Zapadka

  5. Department of Pathology, Wake Forest University Health Sciences, Winston-Salem, NC, 27103, USA

    Ryan T. Mott

Authors
  1. Michael D. Chan
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  2. Albert Attia
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  3. Stephen B. Tatter
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  4. Glenn Lesser
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  5. Michael E. Zapadka
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  6. Ryan T. Mott
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  7. Annette Carter
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  8. Kevin P. McMullen
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  9. Edward G. Shaw
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  10. Thomas E. Ellis
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Correspondence to Michael D. Chan.

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Chan, M.D., Attia, A., Tatter, S.B. et al. Radiation-induced adult medulloblastoma: a two-case report and review of the literature. J Neurooncol 103, 745–749 (2011). https://doi.org/10.1007/s11060-010-0426-z

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  • DOI: https://doi.org/10.1007/s11060-010-0426-z

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