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The MOSART Database: Linking the SART CORS Clinical Database to the Population-Based Massachusetts PELL Reproductive Public Health Data System

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Abstract

Although Assisted Reproductive Technology (ART) births make up 1.6 % of births in the US, the impact of ART on subsequent infant and maternal health is not well understood. Clinical ART treatment records linked to population data would be a powerful tool to study long term outcomes among those treated or not by ART. This paper describes the development of a database intended to accomplish this task. We constructed the Massachusetts Outcomes Study of Assisted Reproductive Technology (MOSART) database by linking the Society of Assisted Reproductive Technologies Clinical Outcomes Reporting System (SART CORS) and the Massachusetts (MA) Pregnancy to Early Life Longitudinal (PELL) data systems for children born to MA resident women at MA hospitals between July 2004 and December 2008. PELL data representing 282,971 individual women and their 334,152 deliveries and 342,035 total births were linked with 48,578 cycles of ART treatment in SART CORS delivered to MA residents or women receiving treatment in MA clinics, representing 18,439 eligible women of whom 9,326 had 10,138 deliveries in this time period. A deterministic five phase linkage algorithm methodology was employed. Linkage results, accuracy, and concordance analyses were examined. We linked 9,092 (89.7 %) SART CORS outcome records to PELL delivery records overall, including 95.0 % among known MA residents treated in MA clinics; 70.8 % with full exact matches. There were minimal differences between matched and unmatched delivery records, except for unknown residency and out-of-state ART site. There was very low concordance of reported use of ART treatment between SART CORS and PELL (birth certificate) data. A total of 3.4 % of MA children (11,729) were identified from ART assisted pregnancies (6,556 singletons; 5,173 multiples). The MOSART linked database provides a strong basis for further longitudinal ART outcomes studies and supports the continued development of potentially powerful linked clinical-public health databases.

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Abbreviations

US:

United States

MA:

Massachusetts

ART:

Assisted Reproductive Technologies

PELL:

Pregnancy to Early Life Longitudinal data system

SART CORS:

Society for Assisted Reproductive Technologies Clinical Outcome Reporting System

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Acknowledgments

This project was supported by NICHD Award Numbers RO1 HD064595 and RO1 HD067270. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Child Health and Human Development or the National Institutes of Health. Other/former MOSART staff: Howard Cabral; Bruce Cohen; Katrina Plummer; Mark Hornstein; Barbara Luke; Qi Yu; Daksha Gopal; Judith Weiss; and Maurizio Macaluso. SART wishes to thank all of its members for providing clinical information to the SART CORS database for use by patients and researchers. Without the efforts of SART members, this research would not have been possible.

Conflict of interest

The authors have no conflicts of interest to disclose. The findings and conclusions in this paper are those of the authors and do not necessarily represent the official position of the Society of Assisted Reproductive Technologies or the Massachusetts Department of Public Health.

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Authors and Affiliations

  1. MGH Center for Child and Adolescent Health Research and Policy, MassGeneral Hospital for Children, 100 Cambridge Street, 15-1545, Boston, MA, 02114, USA

    Milton Kotelchuck

  2. Community Health Sciences, Boston University School of Public Health, Boston, MA, USA

    Lan Hoang, Candice Belanoff & Eugene Declercq

  3. Obstetrics and Gynecology and Pathology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA

    Judy E. Stern

  4. Massachusetts Department of Public Health, Boston, MA, USA

    Hafsatou Diop

Authors
  1. Milton Kotelchuck
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  2. Lan Hoang
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  3. Judy E. Stern
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  4. Hafsatou Diop
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  5. Candice Belanoff
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  6. Eugene Declercq
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Correspondence to Milton Kotelchuck.

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Kotelchuck, M., Hoang, L., Stern, J.E. et al. The MOSART Database: Linking the SART CORS Clinical Database to the Population-Based Massachusetts PELL Reproductive Public Health Data System. Matern Child Health J 18, 2167–2178 (2014). https://doi.org/10.1007/s10995-014-1465-4

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