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Synthesis of urea-pyridyl ligand functionalized mesoporous silica hybrid material for hydrophobic and hydrophilic drug delivery application

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Abstract

In this work, we propose the synthesis of urea-pyridyl (UPy) ligand functionalized mesoporous silica hybrid material as novel and effective drug delivery system for loading/release of both hydrophobic and hydrophilic drugs. For the synthesis of UPy ligand functionalized mesoporous silica hybrid material, the combination of sol–gel co-condensation technique and post silica surface modification method were adapted. The prepared UPy ligand functionalized mesoporous silica hybrid (UPy-MSH) material was characterized by X-ray diffraction, Fourier-transform infrared, N2 adsorption–desorption analysis. The material morphology and mesopore channels were observed by scanning and transmission electron microscopic analyses. The content of modified organic ligand functionalities present in the UPy-MSH material surface was determined by thermogravimetric analysis. The hydrophilic anticancer drug, 5-Fluorouracil and the hydrophobic anti-inflammatory drug, Ibuprofen was used as a model drugs to determine the loading and pH-responsive release efficiency of the synthesized UPy-MSH material under different pH (pH 7.4 and 5.0) conditions, respectively. In addition, the biocompatibility of the UPy-MSH material was evaluated on MDA-MB-231 cells. The experimental results depicted that the synthesized UPy-MSH material is biocompatible and has high drug loading capacity, selective and controlled release of specific drug with respect to the pH condition.

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Acknowledgements

This research was supported by a grant from the Marine Biotechnology Program (20150220) funded by the Ministry of Oceans and Fisheries, Republic of Korea.

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Authors and Affiliations

  1. Marine-Integrated Bionics Research Center, Pukyong National University, Busan, 608-737, Republic of Korea

    Madhappan Santha Moorthy, Subramanian Bharathiraja, Panchanathan Manivasagan, Yunok Oh & Junghwan Oh

  2. Department of Biomedical Engineering and Center for Marine-Integrated Biotechnology (BK21 Plus), Pukyong National University, Busan, 608-737, Republic of Korea

    Bian Jang, Thi Tuong Vy Phan & Junghwan Oh

Authors
  1. Madhappan Santha Moorthy
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  2. Subramanian Bharathiraja
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  3. Panchanathan Manivasagan
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  4. Yunok Oh
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  5. Bian Jang
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  6. Thi Tuong Vy Phan
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  7. Junghwan Oh
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Correspondence to Junghwan Oh.

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Moorthy, M.S., Bharathiraja, S., Manivasagan, P. et al. Synthesis of urea-pyridyl ligand functionalized mesoporous silica hybrid material for hydrophobic and hydrophilic drug delivery application. J Porous Mater 25, 119–128 (2018). https://doi.org/10.1007/s10934-017-0425-y

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