Abstract
Conjugated polymer nanodots are shown to have great potential as probe for fluorescence-based biosensing and bioimaging applications. Yet the need to functionalize these polymer nanodots is hindering their uses in many applications. Here, we report the preparation and encapsulation of fluorescent polymer nanodots inside silica nanoparticles. The facile, template-assisted method has little effect on the fluorescent properties of polymer nanodots. The resulting nanodot-embedded silica nanoparticles can be easily functionalized for downstream applications.
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Wu C, Bull B, Szymanski C, Christensen K, McNeill J (2008) Multicolor conjugated polymer dots for biological fluorescence imaging. ACS Nano 2:2415–2423
Wu C, Szymanski C, McNeill J (2006) Preparation and encapsulation of conjugated polymer nanoparticles. Langmuir 22:2956–2960
Pecher J, Mecking S (2010) Nanoparticles of conjugated polymers. Chem Rev 110:6260–6279
Tuncel D, Demir HV (2010) Conjugated polymer nanoparticles. Nanoscale 2:484–494
Li K, Liu B (2012) Polymer encapsulated conjugated polymer nanoparticles for fluorescence bioimaging. J Mater Chem 22:1257–1264
Tan H, Zhang Y, Wang M, Zhang Z, Zhang X, Yong AM, Wong SY, Chang AY, Chen Z-K, Li X, Choolani M, Wang J (2012) Silica-shell cross-linked micelles encapsulating fluorescent conjugated polymers for targeted cellular imaging. Biomaterials 33:237–246
Lee CS, Chang HH, Jung J, Lee NA, Song NW, Chung BH (2012) A novel fluorescent nanoparticle composed of fluorene copolymer core and silica shell with enhanced photostability. Colloids Surf B Biointerfaces 91:219–225
Grey JK, Kim DY, Norris BC, Miller WL, Barbara PF (2006) Size-dependent spectroscopic properties of conjugated polymer nanoparticles. J Phys Chem B 110:25568–25572
Kurokawa N, Yoshikawa H, Hirota N, Hyodo K, Masuhara H (2004) Size dependent spectroscopic properties and thermochromic behavior in poly(substituted thiophene) nanoparticles. ChemPhysChem 5:1609–1615
Wu C, Szymanski C, Cain Z, McNeill J (2007) Conjugated Polymer Dots for Multiphoton Fluorescence Imaging. J Am Chem Soc 129:12904–12905
Yu J, Wu C, Sahu SP, Fernando LP, Szymanski C, McNeill J (2009) Nanoscale 3D tracking with conjugated polymer nanoparticles. J Am Chem Soc 131:18410–18414
Szymanski C, Wu C, Hooper J, Salazar MA, Perdomo A, Dukes A, McNeill J (2005) Single molecule nanoparticles of the conjugated polymer Meh–PPV, preparation and characterization by near-field scanning optical microscopy. J Phys Chem B 109:8543–8546
Green M, Howes P, Berry C, Argyros O, Thanou M (2009) Simple conjugated polymer nanoparticles as biological labels. Proc R Soc A 465:2751–2759
Feng X, Lv F, Liu L, Tang H, Xing C, Yang Q, Wang S (2010) Conjugated polymer nanoparticles for drug delivery and imaging. ACS Appl. Mater Interfaces 2:2429–2435
Chong H, Nie C, Zhu C, Yang Q, Liu L, Lv F, Wang S (2012) Conjugated polymer nanoparticles for light-activated anticancer and antibacterial activity with imaging capability. Langmuir 28:2091–2098
Wu C, Bull B, Christensen K, McNeill J (2009) Ratiometric single-nanoparticle oxygen sensors for biological imaging. Angew Chem Int Ed 48:2741–2745
Childress ES, Roberts CA, Sherwood DY, Le Guyader CLM, Harbron EJ (2012) Ratiometric fluorescence detection of mercury ions in water by conjugated polymer nanoparticles. Anal Chem 84:1235–1239
Chan Y, Gallina ME, Zhang X, Wu IC, Jin Y, Sun W, Chiu DT (2012) Reversible photoswitching of spiropyran-conjugated semiconducting polymer dots. Anal Chem 84:9431–9438
Kobler J, Moller K, Bein T (2008) Colloidal suspensions of functionalized mesoporous silica nanoparticles. ACS Nano 4:791–799
Sreejith S, Ma X, Zhao Y (2012) Graphene oxide wrapping on squaraine-loaded mesoporous silica nanoparticles for bioimaging. J Am Chem Soc 134:17346–17349
Han L, Wei H, Tu B, Zhao D (2011) A facile one-pot synthesis of uniform core–shell silver nanoparticle@mesoporous silica nanospheres. Chem Commun 47:8536–8538
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This work was partially supported by the National Science Foundation (CBET-1065633).
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Joshi, P.B., Zhang, P. Facile capture of conjugated polymer nanodots in silica nanoparticles to facilitate surface modification. J Mater Sci 50, 3597–3603 (2015). https://doi.org/10.1007/s10853-015-8920-5
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DOI: https://doi.org/10.1007/s10853-015-8920-5