Abstract
This study presents a method of producing biocompatible nanofibrous composites containing antimicrobial polymers which have excellent antimicrobial efficacy. Specifically, antimicrobial cellulose acetate (CA) nanofibrous composites were prepared by adding poly[5,5-dimethyl-3-(3′-triethoxysilylpropyl)hydantoin] (PBA) to the CA solution using the electro-spinning technique followed with curing and exposure to diluted sodium hypochlorite. Scanning electron microscopy images demonstrated that CA nanofibers formed with diameters of 172 ± 62 nm. The chlorinated CA nanofibrous mats showed good UVA stability. The chlorinated CA nanofibrous mats completely inactivated Staphylococcus aureus (gram-positive) and Escherichia coli O157:H7 (gram-negative) within 30 min of contact time. The cell culture assay showed that the N-halamine-modified CA nanofibrous composites are non-toxic in vitro.
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Acknowledgements
The financial support was provided by the National Thousand Young Talents Program. The authors acknowledge helpful discussions with Dr. S.D. Worley (Auburn University) and the assistance in XPS data collection by Dr. Jun Luo (Tsinghua University).
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Jiang, Q., Jiang, Z., Ma, K. et al. Development of cytocompatible antibacterial electro-spun nanofibrous composites. J Mater Sci 49, 6734–6741 (2014). https://doi.org/10.1007/s10853-014-8285-1
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DOI: https://doi.org/10.1007/s10853-014-8285-1