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A continuum model for remodeling in living structures

  • Nano- and micromechanical properties of hierarchical biological materials
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Abstract

A new remodeling theory accounting for mechanically driven collagen fiber reorientation in cardiovascular tissues is proposed. The constitutive equations for the living tissues are motivated by phenomenologically based microstructural considerations on the collagen fiber level. Homogenization from this molecular microscale to the macroscale of the cardiovascular tissue is performed via the concept of chain network models. In contrast to purely invariant-based macroscopic approaches, the present approach is thus governed by a limited set of physically motivated material parameters. Its particular feature is the underlying orthotropic unit cell which inherently incorporates transverse isotropy and standard isotropy as special cases. To account for mechanically induced remodeling, the unit cell dimensions are postulated to change gradually in response to mechanical loading. From an algorithmic point of view, rather than updating vector-valued microstructural directions, as in previously suggested models, we update the scalar-valued dimensions of this orthotropic unit cell with respect to the positive eigenvalues of a tensorial driving force. This update is straightforward, experiences no singularities and leads to a stable and robust remodeling algorithm. Embedded in a finite element framework, the algorithm is applied to simulate the uniaxial loading of a cylindrical tendon and the complex multiaxial loading situation in a model artery. After investigating different material and spatial stress and strain measures as potential driving forces, we conclude that the Cauchy stress, i.e., the true stress acting on the deformed configuration, seems to be a reasonable candidate to drive the remodeling process.

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Authors and Affiliations

  1. Department of Mechanical Engineering, Stanford University, Stanford, CA, 94305, USA

    Ellen Kuhl

  2. Department of Solid Mechanics, School of Engineering Sciences, Royal Institute of Technology, Stockholm, 100 44, Sweden

    Gerhard A. Holzapfel

  3. Institute for Biomechanics, Center for Biomedical Engineering, Graz University of Technology, Graz, 8010, Austria

    Gerhard A. Holzapfel

Authors
  1. Ellen Kuhl
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  2. Gerhard A. Holzapfel
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Correspondence to Ellen Kuhl.

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Kuhl, E., Holzapfel, G.A. A continuum model for remodeling in living structures. J Mater Sci 42, 8811–8823 (2007). https://doi.org/10.1007/s10853-007-1917-y

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  • DOI: https://doi.org/10.1007/s10853-007-1917-y

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