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Synchrony with shunting inhibition in a feedforward inhibitory network

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Abstract

Recent experiments have shown that GABAA receptor mediated inhibition in adult hippocampus is shunting rather than hyperpolarizing. Simulation studies of realistic interneuron networks with strong shunting inhibition have been demonstrated to exhibit robust gamma band (20–80 Hz) synchrony in the presence of heterogeneity in the intrinsic firing rates of individual neurons in the network. In order to begin to understand how shunting can contribute to network synchrony in the presence of heterogeneity, we develop a general theoretical framework using spike time response curves (STRC’s) to study patterns of synchrony in a simple network of two unidirectionally coupled interneurons (UCI network) interacting through a shunting synapse in the presence of heterogeneity. We derive an approximate discrete map to analyze the dynamics of synchronous states in the UCI network by taking into account the nonlinear contributions of the higher order STRC terms. We show how the approximate discrete map can be used to successfully predict the domain of synchronous 1:1 phase locked state in the UCI network. The discrete map also allows us to determine the conditions under which the two interneurons can exhibit in-phase synchrony. We conclude by demonstrating how the information from the study of the discrete map for the dynamics of the UCI network can give us valuable insight into the degree of synchrony in a larger feed-forward network of heterogeneous interneurons.

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Acknowledgements

This work has been supported in part through a grant from the Office of Naval Research (Grant Number N00014-02-1- 1019), the National Institute of Biomedical Imaging and Bioengineering through Collaborative Research in Computational Neuroscience (R01EB004752) and (EB007082) and the Wilder Center of Excellence for Epilepsy Research at the University of Florida. We acknowledge Dr P. Khargonekar, Dr H. Abarbanel and the anonymous reviewer’s for their valuable comments and suggestions on this manuscript.

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Authors and Affiliations

  1. J Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, 32611, USA

    Sachin S. Talathi & Paul R. Carney

  2. Korea Institute of Oriental Medicine, 483 Exporo, Yuseong-gu, Daejeon, 305-811, Republic of Korea

    Dong-Uk Hwang

  3. School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, 85287, USA

    William L. Ditto

Authors
  1. Sachin S. Talathi
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  2. Dong-Uk Hwang
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  3. Paul R. Carney
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  4. William L. Ditto
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Correspondence to Sachin S. Talathi.

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Action Editor: N. Kopell

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Talathi, S.S., Hwang, DU., Carney, P.R. et al. Synchrony with shunting inhibition in a feedforward inhibitory network. J Comput Neurosci 28, 305–321 (2010). https://doi.org/10.1007/s10827-009-0210-2

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  • DOI: https://doi.org/10.1007/s10827-009-0210-2

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