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Brief Report: Relationship Between ADOS-2, Module 4 Calibrated Severity Scores (CSS) and Social and Non-Social Standardized Assessment Measures in Adult Males with Autism Spectrum Disorder (ASD)

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Abstract

The ADOS-2 Modules 1–3 now include a standardized calibrated severity score (CSS) from 1 to 10 based on the overall total raw score. Subsequent research published CSS for Module 4 (Hus, Lord, Journal of Autism and Developmental Disorders 44(8):1996–2012, 2014); however more research is needed to examine the psychometric properties of this CSS. Forty males with ASD completed an assessment battery consisting of ADOS-2 Module 4 and other clinical measures assessing core ASD symptomology and comorbidity. Pearson correlation analyses found that CSS did not correlate with measures that assessed core social deficits of ASD or general psychiatric co-morbidity, but CSS did correlate negatively with intellectual quotient. These findings provide information on the limitations and relevance of CSS to be taken into account in future clinical evaluations of ASD.

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Acknowledgments

This research was supported in part by the Silvio O Conte Center for Oxytocin and Social Cognition from the National Institute of Mental Health 1P50MH100023. We thank Catherine Rice, Nikolaou Loizos, Lauren Castriota and Nichole Evans for their assistance. Portions of this paper have been presented at the annual meeting of the International Society for Autism Research, Baltimore, MD, 2016.

Author Contributions

MJM conceived of the study, conducted the literature review, participated in the design, assisted with data collection, performed the initial statistical analyses, and drafted the manuscript, and co-wrote all revisions. OYO coordinated assessment protocols, participated in the design, collected data and doubled checked reliability of data, and read, edited, and approved original submission. GAC-G assisted with data analyses, and read, edited, and approved initial submission. MJS collected data, and read, edited, and approved initial submission. JFC consulted to data collection process, and read, edited, and approved initial submission. LJY conceived of larger study, secured study finding, provided statistical input, and read, edited, and approved initial submission. EA assisted with design, conducted analyses, produced figures, and read, edited, and approved initial submission and co-drafted all revisions.

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Authors and Affiliations

  1. Department of Psychiatry & Behavioral Sciences, Emory Autism Center, Emory University School of Medicine, 1551 Shoup Court, Decatur, GA, 30033, USA

    Michael J. Morrier, Opal Y. Ousley, Matthew J. Segall & Joseph F. Cubells

  2. Silvio O. Conte Center for Oxytocin and Social Cognition, Emory University School of Medicine, Atlanta, GA, USA

    Michael J. Morrier, Opal Y. Ousley, Gabriella A. Caceres-Gamundi, Matthew J. Segall, Joseph F. Cubells, Larry J. Young & Elissar Andari

  3. Department of Psychiatry and Behavioral Sciences, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, GA, USA

    Larry J. Young & Elissar Andari

  4. Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA

    Joseph F. Cubells

Authors
  1. Michael J. Morrier
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  2. Opal Y. Ousley
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  3. Gabriella A. Caceres-Gamundi
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  4. Matthew J. Segall
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  5. Joseph F. Cubells
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  6. Larry J. Young
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  7. Elissar Andari
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Correspondence to Michael J. Morrier.

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Morrier, M.J., Ousley, O.Y., Caceres-Gamundi, G.A. et al. Brief Report: Relationship Between ADOS-2, Module 4 Calibrated Severity Scores (CSS) and Social and Non-Social Standardized Assessment Measures in Adult Males with Autism Spectrum Disorder (ASD). J Autism Dev Disord 47, 4018–4024 (2017). https://doi.org/10.1007/s10803-017-3293-z

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  • DOI: https://doi.org/10.1007/s10803-017-3293-z

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