Abstract
Autism susceptibility genes likely have effects on continuously distributed autism-related traits, yet few measures of such traits exist. The Broader Phenotype Autism Symptom Scale (BPASS), developed for use with affected children and family members, measures social motivation, social expressiveness, conversational skills, and flexibility. Based on 201 multiplex families, psychometric data on the BPASS are reported. Adequate inter-rater reliability and internal consistency were found. Parents had lower BPASS scores than affected children, after controlling for IQ. Parents and affected children showed overlapping distributions suggesting the BPASS captured variability in traits across groups. BPASS scores were not correlated with ethnicity or parent education; however, some domains were correlated with IQ. The BPASS holds promise as a quantitative phenotypic assessment for genetic studies.
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Acknowledgments
This work was funded by a grant from the National Institute of Child Health and Human Development (U19HD34565), which is part of the NICHD/NIDCD Collaborative Program of Excellence in Autism. We gratefully acknowledge the families who participated in this study, and Julie Osterling who helped developed the BPASS.
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Dawson, G., Estes, A., Munson, J. et al. Quantitative Assessment of Autism Symptom-related Traits in Probands and Parents: Broader Phenotype Autism Symptom Scale. J Autism Dev Disord 37, 523–536 (2007). https://doi.org/10.1007/s10803-006-0182-2
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DOI: https://doi.org/10.1007/s10803-006-0182-2