Skip to main content
SpringerLink
Log in

Effects of childhood exposure to PM2.5 in a Memphis pediatric asthma cohort

  • Published:
Environmental Monitoring and Assessment Aims and scope Submit manuscript

Abstract

The effects of childhood exposure to ambient air pollution and their influences on healthcare utilization and respiratory outcomes in Memphis pediatric asthma cohort are still unknown. This study seeks to (1) investigate individual-level associations between asthma and exposure measures in high asthma rate and low asthma rate areas and (2) determine factors that influence asthma at first year of a child’s life, first 2 years, first 5 years, and during their childhood. Datasets include physician-diagnosed asthma patients, on-road and individual PM2.5 emissions, and high-resolution spatiotemporal PM2.5 estimates. Spatial analytical and logistic regression models were used to analyze the effects of childhood exposure on outcomes. Increased risk was associated with African American (AA) (odds ratio (OR) = 3.09, 95% confidence interval (CI) 2.80–3.41), aged < 5 years old (OR = 1.31, 95% 1.17–1.47), public insurance (OR = 2.80, 95% CI 2.60–3.01), a 2.5-km radius from on-road emission sources (OR = 3.06, 95% CI 2.84–3.30), and a 400-m radius from individual PM2.5 sources (OR = 1.33, 95% CI 1.25–1.41) among the cohort with residence in high asthma rate areas compared to low asthma rates areas. A significant interaction was observed between race and insurance with the odds of AA being approximately five times (OR = 4.68, 95% CI 2.23–9.85), public insurance being about three times (OR = 2.65, 95% CI 1.68–4.17), and children in their first 5 years of life have more hospital visits than other age groups. Findings from this study can guide efforts to minimize emissions, manage risk, and design interventions to reduce disease burden.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  • Acosta, J. C., Banito, A., Wuestefeld, T., Georgilis, A., Janich, P., Morton, J. P., et al. (2013). A complex secretory program orchestrated by the inflammasome controls paracrine senescence. Nature Cell Biology, 15(8), 978–990. https://doi.org/10.1038/ncb2784.

    Article  CAS  Google Scholar 

  • Barnett, S. B. L., & Nurmagambetov, T. A. (2011). Costs of asthma in the United States: 2002-2007. Journal of Allergy and Clinical Immunology, 127(1), 145–152.

    Article  Google Scholar 

  • Ben-Schlomo, Y., & Kuh, D. (2002). A life course approach to chronic disease epidemiology: conceptual models, empirical challenges and interdisciplinary perspectives. International Journal of Epidemiology, 31, 285–293.

    Article  Google Scholar 

  • Berhane, K., Chang, C., McConnell, R., Gauderman, W. J., Avol, E., Rapapport, E., Urman, R., Lurmann, F., & Gilliland, F. (2016). Association of changes in air quality with bronchitis symptoms in children in California, 1993-2012. JAMA., 315(14), 1491–1501. https://doi.org/10.1001/jama.2016.3444.

    Article  CAS  Google Scholar 

  • Boulet, L. P., & Boulay, M. E. (2011). Asthma-related comorbidities. Expert Review of Respiratory Medicine, 5(3), 377–393.

    Article  Google Scholar 

  • Boys, B. L., Martin, R. V., van Donkelaar, A., MacDonell, R., Hsu, N. C., Cooper, M. J., Yantosca, R. M., Lu, Z., Streets, D. G., Zhang, Q., & Wang, S. (2014). Fifteen-year global time series of satellite-derived fine particulate matter. Environmental Science & Technology, 48(19), 11109–11118. https://doi.org/10.1021/es502113p.

    Article  CAS  Google Scholar 

  • Brunekreef, B., & Holgate, S. T. (2002). Air pollution and health. Lancet, 360, 1233–1242.

    Article  CAS  Google Scholar 

  • Brunekreef, B., & Sunyer, J. (2003). Asthma, rhinitis and air pollution: is traffic to blame? [Comment]. The European Respiratory Journal, 21(6), 913–915.

    Article  CAS  Google Scholar 

  • Camacho-Rivera, M., Kawachi, I., Bennett, G. G., & Subramanian, S. V. (2014). Perceptions of neighborhood safety and asthma among children and adolescents in Los Angeles: a multilevel analysis. PLoS One, 9(1), e87524. https://doi.org/10.1371/journal.pone.0087524.

    Article  CAS  Google Scholar 

  • Clark, N. M., Brown, R. W., Parker, E., Robins, T. G., Remick, D. G. J., Philbert, M. A., Keeler, G. J., & Israel, B. A. (1999). Childhood asthma. Environmental Health Perspectives, 107(Suppl 3), 421–429.

    Article  Google Scholar 

  • Deng, Q., Lu, C., Yu, Y., Li, Y., Sundell, J., & Norbäck, D. (2016). Early life exposure to traffic-related air pollution and allergic rhinitis in preschool children. Respiratory Medicine, 121, 67–73.

    Article  Google Scholar 

  • Dockery, D. W., Pope, C. A. I. I. I., Xu, X., Spengler, J. D., Ware, J. H., Fay, M. E., et al. (1993). An association between air pollution and mortality in six U.S. cities. The New England Journal of Medicine, 329(24), 1753–1759.

    Article  CAS  Google Scholar 

  • Durston, S. (2008). Converging methods in studying attention-deficit/hyperactivity disorder: what can we learn from neuroimaging and genetics? Development and Psychopathology, 20(4), 1133–1143.

    Article  Google Scholar 

  • Eaddy, M. T., Cook, C. L., O’Day, K., Burch, S. P., & Cantrell, C. R. (2012). How patient cost-sharing trends affect adherence and outcomes: a literature review. Pharmacy and Therapeutics, 37(1), 45–55.

    Article  Google Scholar 

  • Eggleston, P. A., Buckley, T. J., Breysse, P. N., Wills-Karp, M., Kleeberger, S. R., & Jaakkola, J. J. (1999). The environment and asthma in U.S. inner cities. Environmental Health Perspectives, 107(Suppl 3), 439–450.

    Article  Google Scholar 

  • Fecht, D., Hansell, A. L., Morley, D., Dajnak, D., Vienneau, D., Beevers, S., Toledano, M. B., Kelly, F. J., Anderson, H. R., & Gulliver, J. (2016). Spatial and temporal associations of road traffic noise and air pollution in London: Implications for epidemiological studies. Environment International, 88, 235–242. https://doi.org/10.1016/j.envint.2015.12.001.

    Article  CAS  Google Scholar 

  • Friberg, M. D., Zhai, X., Holmes, H. A., Chang, H. H., Strickland, M. J., Sarnat, S. E., Tolbert, P. E., Russell, A. G., & Mulholland, J. A. (2016). Method for Fusing Observational Data and Chemical Transport Model Simulations To Estimate Spatiotemporally Resolved Ambient Air Pollution. Environmental Science & Technology, 50(7), 3695–3705. https://doi.org/10.1021/acs.est.5b05134.

    Article  CAS  Google Scholar 

  • Giedd, J. N., Lalonde, F. M., Celano, M. J., White, S. L., Wallace, G. L., Lee, N. R., & Lenroot, R. K. (2009). Anatomical brain magnetic resonance imaging of typically developing children and adolescents. Journal of the American Academy of Child and Adolescent Psychiatry, 48(5), 465–470.

    Article  Google Scholar 

  • Gilliland, F., Avol, E., Kinney, P., Jerrett, M., Dvonch, T., Lurmann, F., et al. (2005). Air Pollution Exposure Assessment for Epidemiologic Studies of Pregnant Women and Children: Lessons Learned from the Centers for Children’s Environmental Health and Disease Prevention Research. Environmental Health Perspectives, 113(10), 1447–1454.

    Article  CAS  Google Scholar 

  • Gogtay, N., Giedd, J. N., Lusk, L., Hayashi, K. M., Greenstein, D., Vaituzis, A. C., Nugent, T. F., 3rd, Herman, D. H., Clasen, L. S., Toga, A. W., Rapoport, J. L., & Thompson, P. M. (2004). Dynamic mapping of human cortical development during childhood through early adulthood. Proceedings of the National Academy of Sciences of the United States of America, 101(21), 8174–8179.

    Article  CAS  Google Scholar 

  • Gorai, A. K., Kanchan, Upadhyay, A., Tuluri, F., Goyal, P., & Tchounwou, P. B. (2015). An innovative approach for determination of air quality health index. The Science of the Total Environment, 533, 495–505. https://doi.org/10.1016/j.scitotenv.2015.06.133.

    Article  CAS  Google Scholar 

  • Gottlieb, D. J., O’Connor, G. T., & Beiser, A. S. (1995). Poverty, race, and medication use are correlates of asthma hospitalization rates: a small area analysis in Boston. Chest., 108(1), 28–35. https://doi.org/10.1378/chest.108.1.28.

    Article  CAS  Google Scholar 

  • Hall, A. J., Yee, L. J., & Thomas, S. L. (2002). Life course epidemiology and infectious diseases. International Journal of Epidemiology, 31, 300–301.

    Article  Google Scholar 

  • Halonen, J. I., Blangiardo, M., Toledano, M. B., Fecht, D., Gulliver, J., Anderson, H. R., Beevers, S. D., Dajnak, D., Kelly, F. J., & Tonne, C. (2016). Long-term exposure to traffic pollution and hospital admissions in London. Environmental Pollution, 208(Pt A), 48–57. https://doi.org/10.1016/j.envpol.2015.09.051.

    Article  CAS  Google Scholar 

  • Hertzman, C. (1995). The biological embedding of early experience and its effects on health in adulthood. Annals of the New York Academy of Sciences, 896, 85–95.

    Article  Google Scholar 

  • Huynh, P., Salam, M. T., Morphew, T., Kwong, K. Y. C., & Scott, L. (2010). Residential proximity to freeways is associated with uncontrolled asthma in inner-city Hispanic children and adolescents. The Journal of Allergy, 2010, Article ID 157249, 7. https://doi.org/10.1155/2010/157249.

    Article  Google Scholar 

  • Kanchongkittiphon, W., Gaffin, J. M., & Phipatanakul, W. (2014 Jun). The indoor environment and inner-city childhood asthma. Asian Pacific Journal of Allergy and Immunology, 32(2), 103–110.

    Google Scholar 

  • Kuh, D., Ben-Schlomo, Y., Lynch, J., Hallqvist, J., & Power, C. (2003). Life course epidemiology. Journal of Epidemiology and Community Health, 57, 778–783.

    Article  CAS  Google Scholar 

  • Kulkarni, N., & Grigg, J. (2008). Effect of air pollution on children. Paediatrics and Child Health, 18, 238–243.

    Article  Google Scholar 

  • Lenroot, R., & Giedd, J. N. (2006). Brain development in children and adolescents: insights from anatomical magnetic resonance imaging. Neuroscience & Biobehavioral Reviews, 30(6), 718–729.

    Article  Google Scholar 

  • Levy, J. I., Welker-Hood, L. K., Clougherty, J. E., Dodson, R. E., Steinbach, S., & Hynes, H. P. (2004). Lung function, asthma symptoms, and quality of life for children in public housing in Boston: a case-series analysis. Environmental Health, 3, 13. https://doi.org/10.1186/1476-069X-3-13.

    Article  Google Scholar 

  • Lin, Y., Zou, J., Yang, W., & Li, C. Q. (2018). A Review of Recent Advances in Research on PM2.5 in China. International Journal of Environmental Research and Public Health, 15(3), 438. https://doi.org/10.3390/ijerph15030438.

    Article  CAS  Google Scholar 

  • Mao, J., Xu, X., McPheeters, J. T., Davis, J. R., & Tran, T. N. (2017). Patient characteristics and factors associated with persistent high costs in asthma. Journal of Allergy and Clinical Immunology, 139(2), AB58.

    Article  Google Scholar 

  • McCreanor, J., Cullinan, P., Nieuwenhuijsen, M. J., Stewart-Evans, J., Malliarou, E., Jarup, L., Harrington, R., Svartengren, M., Han, I. K., Ohman-Strickland, P., Chung, K. F., & Zhang, J. (2007). Respiratory effects of exposure to diesel traffic in persons with asthma. The New England Journal of Medicine, 357, 2348–2358. https://doi.org/10.1056/NEJMoa071535.

    Article  CAS  Google Scholar 

  • National Research Council 2015. (2015). Committee on the science of children birth to age 8: deepening and broadening the foundation for success; board on children, youth, and families; Institute of Medicine; Allen LR, Kelly BB, editors. Washington (DC): National Academies Press (US); 23.

  • Nicholas, S. W., Jean-Louis, B., Ortiz, B., Northridge, M., Shoemaker, K., Vaughan, R., Rome, M., Canada, G., & Hutchinson, V. (2005 February). Addressing the childhood asthma crisis in Harlem: the Harlem Children’s zone asthma initiative. American Journal of Public Health, 95(2), 245–249. https://doi.org/10.2105/AJPH.2004.042705.

    Article  Google Scholar 

  • Oyana, T. J., Rogerson, P., & Lwebuga-Mukasa, J. S. (2004). Geographic clustering of adult asthma hospitalization and residential exposure to pollution sites in Buffalo neighborhoods at a U.S.–Canada border crossing point. American Journal of Public Health, 94(7), 1250–1257.

    Article  Google Scholar 

  • Oyana, T. J., Podila, P., Wesley, J. M., Lomnicki, S. M., & Cormier, S. A. (2017). Spatiotemporal patterns of childhood asthma hospitalization and utilization in Memphis Metropolitan Area from 2005 to 2015. Journal of Asthma, 54, 842–855. https://doi.org/10.1080/02770903.2016.1277537.

    Article  Google Scholar 

  • Pope, C. A., III, & Dockery, D. W. (2006). Health effects of fine particulate air pollution: lines that connect. Journal of the Air & Waste Management Association (1995), 56, 709–742.

    Article  CAS  Google Scholar 

  • Pope, C. A., Burnett, R. T., Krewski, D., Jerrett, M., Shi, Y., Calle, E. E., & Thun, M. J. (2009). Cardiovascular mortality and exposure to airborne fine particulate matter and cigarette smoke. Circulation, 120, 941–948.

    Article  CAS  Google Scholar 

  • Ritz, B., & Wilhelm, M. (2008). Ambient air pollution and adverse birth outcomes: methodologic issues in an emerging field. Basic & Clinical Pharmacology & Toxicology, 102, 182–190.

    Article  CAS  Google Scholar 

  • Ritz, B., Wilhelm, M., & Zhao, Y. (2006). Air pollution and infant death in Southern California, 1989–2000. Pediatrics, 118, 493–502.

    Article  Google Scholar 

  • Saenen, E., Horemans, N., Vanhoudt, N., Vandenhove, H., Biermans, G., Van Hees, M., et al. (2015). Induction of Oxidative Stress and Antioxidative Mechanisms in Arabidopsis thaliana after Uranium Exposure at pH 7.5. International Journal of Molecular Sciences, 16(6), 12405–12423. https://doi.org/10.3390/ijms160612405.

    Article  CAS  Google Scholar 

  • Schmidt, C. W. (2007). Environmental connections: a deeper look into mental illness. Environmental Health Perspectives, 115(8), A404–A410.

    Google Scholar 

  • Shankardass, K., Jerrett, M., Dell, S. D., Foty, R., & Stieb, D. (2015). Spatial analysis of exposure to traffic-related air pollution at birth and childhood atopic asthma in Toronto, Ontario. Health & Place, 34, 287–295. https://doi.org/10.1016/j.healthplace.2015.06.001.

    Article  CAS  Google Scholar 

  • Shmool, J. L., Bobb, J. F., Ito, K., Elston, B., Savitz, D. A., Ross, Z., et al. (2015). Area-level socioeconomic deprivation, nitrogen dioxide exposure, and term birth weight in New York City. Environmental Research, 142, 624–632. https://doi.org/10.1016/j.envres.2015.08.019.

    Article  CAS  Google Scholar 

  • Smith, A. D., Heron, J., Mishra, G., Gilthorpe, M. S., Ben-Shlomo, Y., & Tilling, K. (2015). Model selection of the effect of binary exposures over the life course. Epidemiology, 26, 719–726.

    Article  Google Scholar 

  • Soyiri, I. N., Reidpath, D. D., & Sarran, C. (2011). Asthma length of stay in hospitals in London 2001–2006: demographic, diagnostic and temporal factors. PLoS One, 6(11), e27184. https://doi.org/10.1371/journal.pone.0027184.

    Article  CAS  Google Scholar 

  • Spenrath, M. A., Clarke, M. E., & Kutcher, S. (2011). The science of brain and biological development: implications for mental health research, practice and policy. Clarke M, Ghali L, eds. Journal of the Canadian Academy of Child and Adolescent Psychiatry, 20(4), 298–304.

    Google Scholar 

  • Sturdy, P., Bremner, S., Harper, G., Mayhew, L., Eldridge, S., Eversley, J., Sheikh, A., Hunter, S., Boomla, K., Feder, G., Prescott, K., & Griffiths, C. (2012). Impact of asthma on educational attainment in a socioeconomically deprived population: a study linking health, education and social care datasets. PLoS One, 7(11), e43977. https://doi.org/10.1371/journal.pone.0043977.

    Article  CAS  Google Scholar 

  • Sullivan, P. W., & Ghushchyan, V. (2015). The burden of asthma in the United States: updated nationally representative estimates of the cost of asthma. Journal of Allergy and Clinical Immunology, 135(2), AB48.

    Article  Google Scholar 

  • Swartz, L., Callahan, K., Butz, A., Rand, C., Kanchanaraksa, S., Diette, G., et al. (2004). Partnering with an inner city community to conduct an environmental randomized clinical trial in asthma. Environmental Research, 95(2), 156–165.

    Article  CAS  Google Scholar 

  • Tong, S., & Colditz, P. (2004). Air pollution and sudden infant death syndrome: a literature review. Pediatric and Perinatal Epidemiology, 18, 327–335.

    Article  Google Scholar 

  • Van Donkelaar, A., Martin, R. V., Spurr, R. J. D., & Burnett, R. T. (2015). High-resolution satellite-derived PM2.5 from optimal estimation and geographically weighted regression over North America. Environmental Science and Technology, 49, 10482–10491.

    Article  Google Scholar 

  • Van Donkelaar, A., Martin, R. V., Brauer, M., Hsu, N. C., Kahn, R. A., Levy, R. C., Lyapustin, A., Sayer, A. M., & Winker, D. M. (2016). Global estimates of fine particulate matter using a combined geophysical-statistical method with information from satellites, models, and monitors. Environmental Science & Technology, 50(7), 3762–3772. https://doi.org/10.1021/acs.est.5b05833.

    Article  CAS  Google Scholar 

  • Veremchuk, L., Cherpack, N., Gvozdenko, T., & Volkova, M. (2014). Methodology for the assessment of the impact of the atmospheric air pollution on the formation of the levels of overall morbidity rate of bronchial asthma. Gigiena i Sanitariia, 94, 119–122.

    Google Scholar 

  • Vrijheid, M., Slama, R., Robinson, O., Chatzi, L., Coen, M., van den Hazel, P., et al. (2014). The human early-life exposome (HELIX): project rationale and design. Environmental Health Perspectives, 122(6), 535–544. https://doi.org/10.1289/ehp.1307204.

    Article  Google Scholar 

  • Weiss, K. B., Sullivan, S. D., & Lyttle, C. S. (2000). Trends in the cost of illness for asthma in the United States, 1985–1994. Journal of Allergy and Clinical Immunology, 106(3), 493–499.

    Article  CAS  Google Scholar 

  • Wild, C. P. (2012). The exposome: from concept to utility. International Journal of Epidemiology, 41(1), 24–32.

    Article  Google Scholar 

  • Whittemore, A. S., & Korn, E. L. (1980). Asthma and air pollution in the Los Angeles area. American Journal of Public Health, 70(7), 687–696. https://doi.org/10.2105/AJPH.70.7.687.

    Article  CAS  Google Scholar 

  • Yangzong, Y., Shi, Z., Nafstad, P., Håheim, L. L., Luobu, O., & Bjertness, E. (2012). The prevalence of childhood asthma in China: a systematic review. BMC Public Health, 12, 860. https://doi.org/10.1186/1471-2458-12-860.

    Article  Google Scholar 

  • Zhao, J., Bai, J., Shen, K., Xiang, L., Huang, S., Chen, A., Huang, Y., Wang, J., & Ye, R. (2010). Self-reported prevalence of childhood allergic diseases in three cities of China: a multicenter study. BMC Public Health, 10(1), 551–557.

    Article  Google Scholar 

  • Zheng, T., Niu, S., Lu, B., Fan, X., Sun, F., Wang, J., Zhang, Y., Zhang, B., Owens, P., Hao, L., Li, Y., & Leaderer, B. (2002). Childhood asthma in Beijing, China: a population-based case-control study. American Journal of Epidemiology, 156(10), 977–983. https://doi.org/10.1093/aje/kwf127.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Preventive Medicine, College of Medicine, The University of Tennessee Health Science Center, 66 North Pauline Street, Suite 651, Memphis, TN, 38163, USA

    Tonny J. Oyana

  2. Methodist Le Bonheur Healthcare, Memphis, TN, USA

    Pradeep Podila

  3. School of Public Health, The University of Memphis, Memphis, TN, USA

    George E. Relyea

Authors
  1. Tonny J. Oyana
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Pradeep Podila
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. George E. Relyea
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Tonny J. Oyana.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This article is part of the Topical Collection on Geospatial Technology in Environmental Health Applications

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Oyana, T.J., Podila, P. & Relyea, G.E. Effects of childhood exposure to PM2.5 in a Memphis pediatric asthma cohort. Environ Monit Assess 191 (Suppl 2), 330 (2019). https://doi.org/10.1007/s10661-019-7419-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s10661-019-7419-y

Keywords

Search

Navigation