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Elevated Risk for Sessile Serrated Polyps in African Americans with Endometrial Polyps

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Abstract

Background

Colorectal and endometrial lesions increase with age. It is not known if these two precursor lesions in sporadic cases associate with each other.

Aim

To determine the association between colorectal polyps and endometrial polyps (EP) in African Americans.

Methods

We reviewed records of patients referred to gynecology clinics and had colonoscopy at Howard University Hospital from January 2004 to December 2015. We defined cases as all patients who had EP and underwent colonoscopy. For controls, we used EP-free patients who underwent colonoscopy. Logistic regression analysis was used to assess the association between colon polyps and EP.

Results

The median age was 60 years in 118 Cases and 57 years in 664 Controls. The overall colorectal polyps prevalence in the two groups was not statistically different (54% in controls vs. 52% in cases, P = 0.60). Sessile serrated adenoma/polyps (SSPs) were more frequent in cases (8% vs. 2% in controls, P = 0.003). Sigmoid and rectal locations were more prevalent in controls than cases. In multivariate analysis and after adjusting for age, diabetes mellitus (DM), and BMI, SSPs were associated with EP occurrence with an odds ratio of 4.6 (CI 1.2–16.7, P = 0.022).

Conclusion

Colorectal polyp prevalence was similar in EP patients compared to EP-free controls. However, we observed a significant association between higher-risk SSPs in patients with EP. The prevalence of smoking and DM was higher in these patients. Females with EP might benefit from a screening for colonic lesions in an age-independent manner.

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Acknowledgments

This project was supported (in part) by the National Institute on Minority Health and Health Disparities of the National Institutes of Health under Award Number G12MD007597 and NIH CA206010.

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Authors and Affiliations

  1. Department of Medicine and Cancer Research Center, Howard University College of Medicine, 2041 Georgia Avenue, N.W., Washington, DC, 20060, USA

    Hassan Ashktorab, Zaki Sherif, Taraneh Tarjoman, Saman Azam, Ifeanyichukwu Okereke, Akbar Soleimani, Adeyinka O. Laiyemo & Farshad Aduli

  2. Pathology Department and Cancer Research Center, Howard University College of Medicine, Washington, DC, USA

    Edward Lee, Babak Shokrani & Hassan Brim

  3. Departments of Internal Medicine and Human Genetics and Rogel Cancer Center, University of Michigan, Ann Arbor, MI, 48109-5368, USA

    John M. Carethers

  4. Division of Pulmonary, Department of Medicine, University of Pittsburg, Pittsburg, PA, USA

    Mehdi Nouraie

  5. Gastroenterology Division, School of Medicine, Stanford University, Palo Alto, CA, USA

    Aida Habtezion

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  1. Hassan Ashktorab
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  2. Zaki Sherif
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  3. Taraneh Tarjoman
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  4. Saman Azam
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  5. Edward Lee
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  9. John M. Carethers
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  10. Adeyinka O. Laiyemo
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  12. Mehdi Nouraie
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  13. Aida Habtezion
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  14. Hassan Brim
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Correspondence to Hassan Ashktorab.

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Ashktorab, H., Sherif, Z., Tarjoman, T. et al. Elevated Risk for Sessile Serrated Polyps in African Americans with Endometrial Polyps. Dig Dis Sci 65, 2686–2690 (2020). https://doi.org/10.1007/s10620-019-05991-y

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  • DOI: https://doi.org/10.1007/s10620-019-05991-y

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