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Activity and Selectivity Control in Reductive Amination of Butyraldehyde over Noble Metal Catalysts

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Approaches to control selectivity and activity in the catalytic reductive amination of butyraldehyde with ammonia over carbon supported noble metal catalysts (Ru, Rh, Pd, and Pt) were explored. Detailed analysis of the reaction network shows that the Schiff base N-[butylidene]butan-1-amine is the most prominent initial product and, only after nearly all butyraldehyde had been converted to N-[butylidene]butan-1-amine, amines are detected in the product mixture. From this intermediate, good hydrogenolysis catalysts (Ru, Rh) produce mostly butylamine, while catalysts less active in hydrogenolysis (Pd, Pt) lead to the hydrogenation of N-[butylidene]butan-1-amine to mostly dibutylamine.

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Authors and Affiliations

  1. Department Chemie, Lehrstuhl II für Technische Chemie, Technische Universität München, Lichtenbergstrasse 4, D-85747, Garching, Germany

    J. Bódis, T. E. Müller & J. A. Lercher

  2. Department of Organic Chemistry, Babes-Bolyai University, Arany János str. No. 11, 3400, Cluj, Romania

    J. Bódis

  3. DSM Research, P.O. Box 18, 6160, MD, Geleen, The Netherlands

    R. Pestman

  4. Department of Chemical Technology, University of Twente, P.O. Box 217, 7500, AE, Enschede, The Netherlands

    L. Lefferts

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  1. J. Bódis
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  2. L. Lefferts
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  3. T. E. Müller
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  4. R. Pestman
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  5. J. A. Lercher
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Bódis, J., Lefferts, L., Müller, T.E. et al. Activity and Selectivity Control in Reductive Amination of Butyraldehyde over Noble Metal Catalysts. Catal Lett 104, 23–28 (2005). https://doi.org/10.1007/s10562-005-7431-4

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  • DOI: https://doi.org/10.1007/s10562-005-7431-4

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