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Oxygen regulates molecular mechanisms of cancer progression and metastasis

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Abstract

Oxygen is the basic molecule which supports life and it truly is “god's gift to life.” Despite its immense importance, research on “oxygen biology” has never received the light of the day and has been limited to physiological and biochemical studies. It seems that in modern day biology, oxygen research is summarized in one word “hypoxia.” Scientists have focused on hypoxia-induced transcriptomics and molecular–cellular alterations exclusively in disease models. Interestingly, the potential of oxygen to control the basic principles of biology like homeostatic maintenance, transcription, replication, and protein folding among many others, at the molecular level, has been completely ignored. Here, we present a perspective on the crucial role played by oxygen in regulation of basic biological phenomena. Our conclusion highlights the importance of establishing novel research areas like oxygen biology, as there is great potential in this field for basic science discoveries and clinical benefits to the society.

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Acknowledgments

The manuscript is supported by Swiss Cancer league research grant to Rajan Gogna and Eduardo Moreno.

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Authors and Affiliations

  1. Institute of Cell Biology, University of Bern, Baltzerstrasse 4, Bern, 3012, Switzerland

    Esha Madan, Eduardo Moreno & Rajan Gogna

  2. Experimental and Molecular Pediatric Cardiology, German Heart Center Munich at the Technical University Munich, Lazarettstrasse 36, Munich, 80636, Germany

    Kartik Gupta

  3. School of Veterinary Medicine, St. George’s University, University Centre, St. George’s, Grenada-WI

    Muzzammil Sayyid

  4. Clinical Research and Translational Therapeutics Lab, University of New Mexico Cancer Center, Albuquerque, NM, 87131, USA

    Hugo Arias-Pulido

  5. Complex Biological Systems Alliance, North Andover, MA, 01845, USA

    Hugo Arias-Pulido

  6. Norris Cotton Cancer Center, Geisel School of Medicine, Dartmouth College, Lebanon, NH, 03756, USA

    Periannan Kuppusamy

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  1. Kartik Gupta
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  2. Esha Madan
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  7. Rajan Gogna
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Correspondence to Rajan Gogna.

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Gupta, K., Madan, E., Sayyid, M. et al. Oxygen regulates molecular mechanisms of cancer progression and metastasis. Cancer Metastasis Rev 33, 183–215 (2014). https://doi.org/10.1007/s10555-013-9464-2

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