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Family history and age at onset of breast cancer in Hispanic and non-Hispanic white women

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Abstract

Objectives

To evaluate the association between family history of breast cancer and breast cancer risk among Hispanic and non-Hispanic white (NHW) women.

Methods

Logistic regression models were used to compute unadjusted and adjusted odds ratios (ORs) and 95% confidence intervals (CIs) using data collected from the 4-Corners Breast Cancer Study, a population-based case–control study of breast cancer conducted in the Southwest United States (3,074 NHW and 1,647 Hispanic women).

Results

The association between family history of breast cancer and early-onset breast cancer risk differs among NHW and Hispanic women. Among women <50 years old, having a family history of breast cancer was associated with a greater increase in risk among NHWs, with an OR of 2.34 (95% CI: 1.64–3.35) when compared to an OR of 1.32 (95% CI: 0.82–2.19) for Hispanics. This difference in risk was not observed among women 50 years and older, with an OR of 1.69 (95% CI: 1.34–2.13) for NHW and 1.47 (95% CI: 1.03–2.10) for Hispanics.

Conclusions

Family history of breast cancer poses a greater risk for early-onset breast cancers among NHW when compared to Hispanic women and may reflect ethnic differences in certain predisposing genetic factors that promote breast cancer development.

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Acknowledgments

The authors acknowledge the contributions of Leslie Palmer, Roger Edwards, Tara Patton, Jason Witter, and Kelly May to data collection and management. This study was funded by the National Cancer Institute, National Institutes of Health, Department of Health and Human Services (CA078682, CA078762, CA078552, and CA078802).

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Authors and Affiliations

  1. Department of Preventive Medicine and Biometrics, University of Colorado at Denver and Health Sciences, Mail Stop F-519, 13001 E. 17th Place, Aurora, CO, 80045, USA

    Betsy Risendal & Tim E. Byers

  2. Department of Biology, University of Colorado at Colorado Springs, Colorado Springs, CO, USA

    Lisa M. Hines

  3. Division of Epidemiology, University of Utah School of Medicine, Salt Lake City, UT, USA

    Carol Sweeney, Martha L. Slattery & Karen Curtin

  4. Moffitt Cancer Center, Tampa, FL, USA

    Anna R. Giuliano

  5. Department of Epidemiology & Population Health, University of Louisville, Louisville, KY, USA

    Kathy B. Baumgartner

Authors
  1. Betsy Risendal
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  2. Lisa M. Hines
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  3. Carol Sweeney
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  4. Martha L. Slattery
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  5. Anna R. Giuliano
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  6. Kathy B. Baumgartner
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  7. Karen Curtin
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  8. Tim E. Byers
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Corresponding author

Correspondence to Betsy Risendal.

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Risendal, B., Hines, L.M., Sweeney, C. et al. Family history and age at onset of breast cancer in Hispanic and non-Hispanic white women. Cancer Causes Control 19, 1349–1355 (2008). https://doi.org/10.1007/s10552-008-9206-x

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  • DOI: https://doi.org/10.1007/s10552-008-9206-x

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