Abstract
Preference ratings are used to quantify quality of life in analyses used for health care policymaking. Subjects indicated how many years of their life expectancy they would trade to avoid BRCA mutations, breast/ovarian cancer, and five preventive measures including prophylactic surgery, annual mammograms, and annual magnetic resonance imaging (MRI). Among 243 respondents, both the 83 women with mutations and the 160 controls rated mammography highest (most favorably), MRI next highest, having a child with a mutation lowest, and ovarian cancer next lowest. Controls rated prophylactic surgery higher than cancer (P < 0.01), but women with mutations did not. In logistic regression, controls were twice as willing as women with mutations to trade time except for screening modalities; younger, lower-income, and non-white women were more willing to trade time than older, higher-income, and white women. Our findings support the use of average-risk individuals’ time trade-off preference ratings for health care policy development.
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Supported in part by grant no. CRTG-98-260-01 from the American Cancer Society, Atlanta, GA (Spin Odyssey), and the Avon Breast Cancer Research and Care Program, and the Women-at-Risk Program
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The authors have no conflict of interest to disclose: An initial version of the study Abstract # 1708 was presented at the ASCO annual meeting 2007 and cited in the Journal of Clinical Oncology.
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Grann, V.R., Patel, P., Bharthuar, A. et al. Breast cancer-related preferences among women with and without BRCA mutations. Breast Cancer Res Treat 119, 177–184 (2010). https://doi.org/10.1007/s10549-009-0373-6
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DOI: https://doi.org/10.1007/s10549-009-0373-6