Abstract
Desferrioxamine (DFO) is a potent iron chelator used in the treatment of iron overload (IO) disorders. However, due to its low cell permeability and fast clearance, DFO administration is usually prolonged and of limited use for the treatment of IO in tissues such as the brain. Caffeine is a safe, rapidly absorbable molecule that can be linked to other compounds to improve their cell permeability. In this work, we successfully prepared and described DFO-caffeine, a conjugate with iron scavenging ability, antioxidant properties and enhanced permeation in the HeLa cell model.
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Acknowledgments
This work was supported by funds from FAPESP and CNPq (Brazilian agencies). ECPA received a MSc grant from CNPq and DG received a postdoctoral fellowship grant from FAPESP. The authors are grateful to Dr. C. W. Liria for technical assistance in RP-HPLC and LC–MS analysis.
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Alta, E.C.P., Goswami, D., Machini, M.T. et al. Desferrioxamine-caffeine (DFCAF) as a cell permeant moderator of the oxidative stress caused by iron overload. Biometals 27, 1351–1360 (2014). https://doi.org/10.1007/s10534-014-9795-7
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DOI: https://doi.org/10.1007/s10534-014-9795-7