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High Rate of Discontinuation May Diminish PrEP Coverage Among Young Men Who Have Sex with Men

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Abstract

Understanding pre-exposure prophylaxis (PrEP) discontinuation is key to maximizing its effectiveness at the individual and population levels. Data came from the RADAR cohort study of MSM aged 16–29 years, 2015–2017. Participants included those who reported past 6-month PrEP use and discontinued its use by the interview date. Of the 197 participants who had used PrEP in the past 6 months, 65 discontinued use. Primary reasons for PrEP discontinuation included trouble getting to doctor’s appointments (14, 21.5%) and issues related to insurance coverage or loss (13, 20.0%). Few (21%) who discontinued spoke to their doctor first, which has important implications for future long acting formulations.

Resumen

Es importante entender la interrupción en el uso de PrEP para maximizar su efectividad a nivel individual y poblacional. Los datos proceden de RADAR, un estudio de cohorte de hombres que tienen sexo con hombres entre 16-29 años de edad. Se incluyeron participantes que reportaron haber usado PrEP en los últimos seis meses que posteriormente descontinuaron su uso. De los 197 participantes que usaron PrEP en los últimos 6 meses, 65 habían dejado de usar PrEP. Dentro de los motivos principales por los cuales dejaron de usar PrEP se encuentran dificultades para llegar a consultas médicas (14, 21.5%) y otras dificultades relacionadas con la cobertura o pérdida de seguro médico (13, 20.0%). Pocos (21%) indicaron haber consultado la descontinuacion de PrEP con su médico, lo cual presenta implicaciones importantes con respecto a futuras formulaciones de acción prolongada.

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Acknowledgements

This work was supported by a Grant from the National Institute on Drug Abuse at the National Institutes of Health (U01DA036939; PI: Mustanski). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute on Drug Abuse or the National Institutes of Health. The sponsor had no involvement in the conduct of the research or the preparation of the article. The authors would like to thank the entire RADAR Research Team, particularly Dr. Thomas Remble and Antonia Clifford for overseeing the project and Daniel T. Ryan for data management. We also thank the RADAR participants for sharing their experiences with us.

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Authors and Affiliations

  1. Department of Medical Social Sciences, Northwestern University, 625 N Michigan Ave Suite 14-044A, Chicago, IL, 60611, USA

    Ethan Morgan, Daniel T. Ryan, Michael E. Newcomb & Brian Mustanski

  2. Institute for Sexual and Gender Minority Health and Wellbeing, Northwestern University, Chicago, IL, USA

    Ethan Morgan, Daniel T. Ryan, Michael E. Newcomb & Brian Mustanski

Authors
  1. Ethan Morgan
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  2. Daniel T. Ryan
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  3. Michael E. Newcomb
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  4. Brian Mustanski
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Correspondence to Ethan Morgan.

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The authors declare that they have no conflicts of interest.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the Ethical Standards of the Institutional and/or National Research Committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Morgan, E., Ryan, D.T., Newcomb, M.E. et al. High Rate of Discontinuation May Diminish PrEP Coverage Among Young Men Who Have Sex with Men. AIDS Behav 22, 3645–3648 (2018). https://doi.org/10.1007/s10461-018-2125-2

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  • DOI: https://doi.org/10.1007/s10461-018-2125-2

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