Abstract
The aim of this study was to investigate the effects of transitioning from non-injection heroin use to injection drug use on sexual risk behavior. Non-injecting heroin users age 16–30 were enrolled from 2002 to 2005, and were re-interviewed at 6-month intervals for up to three years; 561 participants completed at least one follow-up interview. The majority of participants were non-Hispanic (NH) Black (54 %), 23 % were Hispanic, and 21 % were NH white. During follow-up, 154 participants (27.5 %) transitioned to injecting drugs. Logistic regression analyses were conducted using generalized estimating equations (GEE) to estimate the effect of transition to injection drug use on changes in sexual risk behavior during follow-up. Transition to injection drug use during follow-up was associated with increased likelihood of sexual risk behavior, especially for men. Harm reduction efforts that focus on preventing initiation or return to injection among non-injecting drug users may also ameliorate HIV sexual risk behaviors.
Similar content being viewed by others
References
Santibanez S, Garfein R, Swartzendruber A, Purcell D, Paxton L, Greenberg A. Update and overview of practical epidemiologic aspects of HIV/AIDS among injection drug users in the United States. J Urban Health. 2006;83(1):86–100.
Booth RE, Kwiatkowski CF, Chitwood DD. Sex related HIV risk behaviors: differential risks among injection drug users, crack smokers, and injection drug users who smoke crack. Drug Alcohol Depend. 2000;58(3):219–26.
Huo D, Ouellet LJ. Needle exchange and sexual risk behaviors among a cohort of injection drug users in Chicago, Illinois. Sex Transm Dis. 2009;36(1):35–40.
Kapadia F, Latka MH, Wu Y, Strathdee SA, Mackesy-Amiti ME, Hudson SM, et al. Longitudinal determinants of consistent condom use by partner type among young injection drug users: the role of personal and partner characteristics. AIDS Behav. 2011;15(7):1309–18.
Hagan H, Perlman DC, Des Jarlais DC. Sexual risk and HIV infection among drug users in New York City: a pilot study. Subst Use Misuse. 2011;46(2/3):201–7.
Arasteh K, Des Jarlais DC, Perlis TE. Alcohol and HIV sexual risk behaviors among injection drug users. Drug Alcohol Depend. 2008;95(1–2):54–61.
Neaigus A, Gyarmathy VA, Miller M, Frajzyngier V, Zhao M, Friedman SR, et al. Injecting and sexual risk correlates of HBV and HCV seroprevalence among new drug injectors. Drug Alcohol Depend. 2007;89(2–3):234–43.
DesJarlais DC, Arasteh K, McKnight C, Hagan H, Perlman DC, Semaan S. Associations between herpes simplex virus type 2 and HCV with HIV among injecting drug users in New York City: the current importance of sexual transmission of HIV. Am J Public Health. 2011;101(7):1277–83.
Armstrong GL, Wasley A, Simard EP, McQuillan GM, Kuhnert WL, Alter MJ. The prevalence of hepatitis C virus infection in the United States, 1999 through 2002. Ann Intern Med. 2006;144(10):705–14.
Strathdee SA, Galai N, Safaiean M, Celentano DD, Vlahov D, Johnson L, et al. Sex differences in risk factors for HIV seroconversion among injection drug users: a 10-Year perspective. Arch Intern Med. 2001;161(10):1281–8.
Strathdee SA. Sexual HIV transmission in the context of injection drug use: implications for interventions. Int J Drug Policy. 2003;14(1):79–81.
Kral AH, Bluthenthal RN, Lorvick J, Gee L, Bacchetti P, Edlin BR. Sexual transmission of HIV-1 among injection drug users in San Francisco, USA: risk-factor analysis. Lancet. 2001;357(9266):1397–401.
Evans JL, Hahn JA, Page-Shafer K, Lum PJ, Stein ES, Davidson PJ, et al. Gender differences in sexual and injection risk behavior among active young injection drug users in San Francisco (the UFO Study). J Urban Health. 2003;80(1):137–46.
Fuller CM, Vlahov D, Ompad DC, Shah N, Arria A, Strathdee SA. High-risk behaviors associated with transition from illicit non-injection to injection drug use among adolescent and young adult drug users: a case-control study. Drug Alcohol Depend. 2002;66(2):189–98.
Miller CL, Pearce ME, Moniruzzaman A, Thomas V, Christian W, Schechter MT, et al. The Cedar Project: risk factors for transition to injection drug use among young, urban Aboriginal people. Can Med Assoc J. 2011;183(10):1147–54.
Griffiths P, Gossop M, Powis B, Strang J. Transitions in patterns of heroin administration: a study of heroin chasers and heroin injectors. Addiction. 1994;89(3):301–9.
Grund J-PC. From the straw to the needle? Determinants of heroin administration routes. In: Inciardi JA, Harrison LD, editors. Heroin in the Age of Crack Cocaine. Thousand Oaks, CA: Sage; 1998. p. 215–58.
Neaigus A, Miller M, Friedman SR, Hagen DL, Sifaneck SJ, Ildefonso G, et al. Potential risk factors for the transition to injecting among non-injecting heroin users: a comparison of former injectors and never injectors. Addiction. 2001;96(6):847–60.
Neaigus A, Gyarmathy VA, Miller M, Frajzyngier VM, Friedman SR, Des Jarlais DC. Transitions to injecting drug use among noninjecting heroin users: social network influence and individual susceptibility. J Acquir Immune Defic Syndr. 2006;41(4):493–503.
Roy É, Haley N, Leclerc P, Cédras L, Blais L, Boivin J-F. Drug injection among street youths in Montreal: predictors of initiation. J Urban Health. 2003;80(1):92–105.
Sherman SG, Smith L, Laney G, Strathdee SA. Social influences on the transition to injection drug use among young heroin sniffers: a qualitative analysis. Int J Drug Policy. 2002;13(2):113–20.
Valdez A, Cepeda A, Neaigus A, Russell A. Heroin transition risk among daily and non-daily cannabis users who are non-injectors of heroin. Int J Drug Policy. 2008;19(6):442–9.
Broz D, Ouellet LJ. Prevalence and correlates of former injection drug use among young noninjecting heroin users in Chicago. Subst Use Misuse. 2010;45(12):2000–25.
Garfein RS, Swartzendruber A, Ouellet LJ, Kapadia F, Hudson SM, Thiede H, et al. Methods to recruit and retain a cohort of young-adult injection drug users for the Third Collaborative Injection Drug Users Study/Drug Users Intervention Trial (CIDUS III/DUIT). Drug Alcohol Depend. 2007;91(Supplement 1):S4–17.
Broz D. Transitions to injection and risk of HIV, HBV and HCV among young non-injecting heroin users in Chicago [Ph.D. dissertation]. Chicago: University of Illinois at Chicago, United States; 2009.
Des Jarlais DC, Paone D, Milliken J, Turner CF, Miller H, Gribble J, et al. Audio-computer interviewing to measure risk behaviour for HIV among injecting drug users: a quasi-randomised trial. Lancet. 1999;353(9165):1657–61.
Turner CF, Ku L, Rogers SM, Lindberg LD, Pleck JH, Sonenstein FL. Adolescent sexual behavior, drug use, and violence: increased reporting with computer survey technology. Science. 1998;280(5365):867–73.
Acknowledgments
This study was supported by a grant from the National Institute on Drug Abuse #R01DA012068. The authors thank Maggie Parker for data analysis, the study participants for the time and effort they contributed to this study, and the project staff who administered the coupon referral system, collected data, and otherwise operated field sites in a manner welcoming to potential participants. We also wish to recognize the following people for their contributions to the development and/or implementation of the Chicago NIHU-HIT study: Angus Atkins-Trimnell, James Crues, David Cosey, Jaime Delgado, Julio Garcia, Michelle Giles, Erin Kubalanza, Floyd McGee, and Michael Phillips.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Mackesy-Amiti, M.E., Boodram, B., Williams, C. et al. Sexual Risk Behavior Associated with Transition to Injection Among Young Non-Injecting Heroin Users. AIDS Behav 17, 2459–2466 (2013). https://doi.org/10.1007/s10461-012-0335-6
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10461-012-0335-6