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Could Spatial Heterogeneity in Human Vocal Fold Elastic Properties Improve the Quality of Phonation?

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Abstract

The physical mechanisms leading to the acoustic and perceptual qualities of voice are not well understood. This study examines the spatial distribution of biomechanical properties in human vocal folds and explores the consequences of these properties on phonation. Vocal fold lamina propria specimens isolated from nine excised human male larynges were tested in uniaxial tension (six from non-smokers, three from smokers). An optical method was employed to determine the local stretch, from which the elastic modulus of three segments in the anterior-posterior direction was calculated. Several specimens exhibited a significant heterogeneity in the modulus with the middle segment stiffer than the other segments. It was concluded that such modulus gradients are stronger in specimens from non-smokers than smokers. To understand the functional implications of a modulus gradient, the first eigenmode of vibration was calculated with a finite element model. With a modulus gradient, the vocal fold’s eigenmode deflection was spread along the anterior-posterior length, whereas for a homogeneous modulus distribution, the deflection was more focused around the mid-coronal plane. Consequently, the strong modulus gradient may enable more complete glottal closure, which is important for normal phonation, while a more homogeneous modulus may be responsible for poor glottal closure and a perceived “breathy” voice.

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  1. Aurora Scientific Model 300B-LR, Aurora, Ontario, Canada.

  2. Allied Vision Technologies, Stingray F-033B.

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Acknowledgments

The authors are grateful to the National Institutes of Health (NIDCD Grant R01 DC006101) for funding this investigation. J.E. Kelleher is thankful to the National Science Foundation for support a graduate research fellowship. We would also like to thank Erin Henslee, Mindy Du, and Elhum Naseri for their skillful assistance in the experimental measurements.

Conflict of interest

No conflict of interest exists which would have inappropriately influenced this work.

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Authors and Affiliations

  1. School of Mechanical Engineering, Purdue University, 585 Purdue Mall, West Lafayette, IN, 47907, USA

    Jordan E. Kelleher & Thomas Siegmund

  2. Otolaryngology–Head and Neck Surgery, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, 75390, USA

    Roger W. Chan

  3. Biomedical Engineering, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, 75390, USA

    Roger W. Chan

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  1. Jordan E. Kelleher
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Correspondence to Thomas Siegmund.

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Associate Editor Eiji Tanaka oversaw the review of this article.

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Kelleher, J.E., Siegmund, T. & Chan, R.W. Could Spatial Heterogeneity in Human Vocal Fold Elastic Properties Improve the Quality of Phonation?. Ann Biomed Eng 40, 2708–2718 (2012). https://doi.org/10.1007/s10439-012-0609-1

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