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Prognostic factors in trabeculectomy with mitomycin C having history of previous glaucoma surgery

  • Clinical Investigation
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Abstract

Purpose

To evaluate the prognostic factors for surgical outcomes of subsequent trabeculectomy with mitomycin C (MMC) after prior incisional glaucoma surgery.

Methods

We reviewed medical records of a total cohort of 781 trabeculectomies with MMC, and selected 125 patients (125 eyes). The primary endpoints included persistent intraocular pressure (IOP) of ≥21 or <5 mmHg, the need for additional glaucoma surgery and deterioration of visual acuity to no light perception. Univariate and Multivariate analyses were performed by using the Cox proportional hazards model.

Results

The mean follow-up period was 26.8 months. The probabilities of success at 1, 2, and 3 years were 80.6, 72.2, and 70.6 %, respectively. Multivariate analysis showed that a shorter time interval between prior glaucoma surgery and subsequent trabeculectomy [relative risk (RR), 0.8867/year; P = 0.0090] and the number of prior trabeculectomies (RR, 2.2645; P = 0.0029) were significant prognostic factors for subsequent failure of trabeculectomy with MMC.

Conclusion

A short time period between prior glaucoma surgery and subsequent trabeculectomy and the number of prior trabeculectomies are associated with surgical failure of subsequent trabeculectomy with MMC.

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Acknowledgments

This work was supported in part by JSPS KAKENHI Grant Number 23390403, 23791994.

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Authors and Affiliations

  1. Department of Ophthalmology, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, Japan

    Nanako Awai-Kasaoka, Toshihiro Inoue, Minako Ogata-Iwao & Hidenobu Tanihara

  2. Department of Ophthalmology, Faculty of Medical Science, University of Fukui, Fukui, Japan

    Masaru Inatani & Yuji Takihara

Authors
  1. Nanako Awai-Kasaoka
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  2. Toshihiro Inoue
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  3. Masaru Inatani
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  4. Yuji Takihara
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  5. Minako Ogata-Iwao
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  6. Hidenobu Tanihara
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Corresponding author

Correspondence to Toshihiro Inoue.

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Awai-Kasaoka, N., Inoue, T., Inatani, M. et al. Prognostic factors in trabeculectomy with mitomycin C having history of previous glaucoma surgery. Jpn J Ophthalmol 57, 514–519 (2013). https://doi.org/10.1007/s10384-013-0257-5

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  • DOI: https://doi.org/10.1007/s10384-013-0257-5

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