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A pilot study of weekly docetaxel chemotherapy combined with regional hyperthermia for pretreated stage III non-small cell lung cancer

  • Published:
The Chinese-German Journal of Clinical Oncology

Abstract

Objective

To evaluate the feasibility and therapeutic effect of chemotherapy combined with regional radio frequency hyperthermia for pretreated locally advanced non-small cell lung cancer.

Methods

29 patients with stage IIIb non-small cell lung cancer were enrolled in present study, administered chemotherapy up to 4 cycles and radio frequency hyperthermia up to 32 times. The primary end points were grade 3, 4 hematological or non-hematological toxicities and progression free survival, the secondary end points were response rate, tumor control rate and overall survival. Method of Kaplan-Meier was used to do the survival analysis.

Results

21 patients completed whole treatment. The most common grade 3, 4 toxicity was neutropenia (24.1%). Median progression free survival was 4 months (range 0–13 months), one year progression free survival rate was 10.3%. Overall response rate was 25.9%, tumor control rate was 66.6%. Median overall survival was 11 months (range 2–18+ months), one year overall survival rate was 44.8%.

Conclusion

Treatment of chemotherapy in conjunction with regional hyperthermia was safe and well tolerant, and it showed an impressive tumor control rate and an acceptable one year progression free survival.

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Authors and Affiliations

  1. Cancer Center of Huaxi Hospital, Sichuan University, Chengdu, 610041, China

    Jiang Zhu, Yongshu Diao, Ming Jiang & Yu Yang

Authors
  1. Jiang Zhu
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  2. Yongshu Diao
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  3. Ming Jiang
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  4. Yu Yang
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Correspondence to Jiang Zhu.

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Zhu, J., Diao, Y., Jiang, M. et al. A pilot study of weekly docetaxel chemotherapy combined with regional hyperthermia for pretreated stage III non-small cell lung cancer. Chin. -Ger. J. Clin. Oncol. 7, 35–39 (2008). https://doi.org/10.1007/s10330-007-0109-1

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  • DOI: https://doi.org/10.1007/s10330-007-0109-1

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