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Surface Motion of Tympanic Membrane in a Chinchilla Model of Acute Otitis Media

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Abstract

The conductive hearing loss caused by acute otitis media (AOM) is commonly related to a reduction of the tympanic membrane (TM) mobility in response to sound stimuli. However, spatial alterations of the TM surface motion associated with AOM have rarely been addressed. In this study, the TM surface motion was determined using scanning laser Doppler vibrometry (SLDV) in a chinchilla model of AOM. The AOM was established by transbullar injection of nontypeable Haemophilus influenzae. The TM surface vibration was measured in control (uninfected) animals and two AOM groups of animals: 4 days (4D) and 8 days (8D) post inoculation. To quantify the effect of middle ear pressure in those infected ears, the SLDV measurement was first conducted in unopened AOM ears and then in middle ear pressure released ears. Results showed that middle ear infection generally reduced the TM displacement across the entire surface, but the reduction in the umbo displacement over the time course, from 4 to 8 days post inoculation, was less than the reduction in the displacement at the center of each quadrant. The presence of middle ear fluid shifted the occurrence of traveling-wave-like motion on the TM surface to lower frequencies. The observation of the spatial variations of TM surface motion from this study will help refine our understanding of the middle ear sound transmission characteristics in relation to AOM.

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Acknowledgments

The authors thank Dr. Xiangming Zhang and Dr. Xiying Guan, former graduate students in the Biomedical Engineering Lab at the University of Oklahoma, and Mario Pineda, at Polytec Inc., for participating in SLDV measurement. This work was supported by NIH R01DC011585.

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  1. School of Aerospace and Mechanical Engineering and Biomedical Engineering Center, University of Oklahoma, 865 Asp Avenue, Room 200, Norman, OK, 73019, USA

    Xuelin Wang & Rong Z. Gan

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  1. Xuelin Wang
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  2. Rong Z. Gan
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Correspondence to Rong Z. Gan.

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Wang, X., Gan, R.Z. Surface Motion of Tympanic Membrane in a Chinchilla Model of Acute Otitis Media. JARO 19, 619–635 (2018). https://doi.org/10.1007/s10162-018-00683-2

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  • DOI: https://doi.org/10.1007/s10162-018-00683-2

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