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Electrosynthesis and characterization of poly(hydroxy-methylated-3,4-ethylenedioxythiophene) film in aqueous micellar solution and its biosensing application

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Abstract

A new and efficient synthetic route to hydroxymethylated-3,4-ethylenedioxylthiophene (EDOT-MeOH) was developed by a simple four-step sequence, and its global yield was approximately 41.06%. The poly(hydroxymethylated-3,4-ethylenedioxylthiophene) (PEDOT-MeOH) film was electrosynthesized in aqueous sodium dodecylsulfate micellar solutions and characterized by different methods. The EDOT-MeOH possessed better water solubility, and lower onset oxidation potential than EDOT. The as-obtained PEDOT-MeOH film displayed good reversible redox activity, stability and capacitance properties in a monomer-free electrolyte, especially the good solubility of PEDOT-MeOH film in strong polar organic solvents such as dimethyl sulfoxide and tetrahydrofuran created a potential application in many different fields. Fluorescent spectra indicated that PEDOT-MeOH was a yellow-green-light-emitter with maximum emission at 568 nm. The as-formed PEDOT-MeOH film had good biocompatibility and was used for fabricating the electrochemical vitamin C biosensor. The proposed biosensor showed a linear range of 3 × 10−6 mol/L to 1.2 × 10−2 mol/L with the detection limit of 1 μmol/L, a sensitivity of 95.6 μA (mmol/L)− cm−2, and a current response time less than 10 s and a fairly good stability (The relative standard deviation was 0.43% for 20 successive assays, the proposed biosensor still retained 93.5% of bioactivity after 15 days storage. This result indicated that the prepared PEDOT-MeOH film as immobilization matrix of biologically-active species could be a promising candidate for the design and application of biosensor.

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Authors and Affiliations

  1. School of Pharmacy, Jiangxi Science & Technology Normal University, Nanchang, 330013, China

    Yao Lu, Bao-yang Lu, Xue-min Duan  (段学民) & Long Zhang

  2. Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science & Technology Normal University, Nanchang, 330013, China

    Yao Lu, Yang-ping Wen, Jing-kun Xu  (徐景坤), Long Zhang & Yao Huang

Authors
  1. Yao Lu
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  2. Yang-ping Wen
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  3. Bao-yang Lu
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  4. Xue-min Duan  (段学民)
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  5. Jing-kun Xu  (徐景坤)
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  6. Long Zhang
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  7. Yao Huang
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Corresponding authors

Correspondence to Xue-min Duan  (段学民) or Jing-kun Xu  (徐景坤).

Additional information

This work was financially supported by the NSFC (Nos. 50963002, 51073074), Jiangxi Provincial Department of Education (GJJ10678, GJJ11590), Natural Science Foundation of Jiangxi Province (2010GZH0041, 20114BAB203015) and Jiangxi Science & Technology Normal University (KY2010ZY13).

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Lu, Y., Wen, Yp., Lu, By. et al. Electrosynthesis and characterization of poly(hydroxy-methylated-3,4-ethylenedioxythiophene) film in aqueous micellar solution and its biosensing application. Chin J Polym Sci 30, 824–836 (2012). https://doi.org/10.1007/s10118-012-1195-2

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  • DOI: https://doi.org/10.1007/s10118-012-1195-2

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