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Late infectious complications after cord blood stem cell transplantation

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Abstract

The slower engraftment kinetics and impaired immune reconstitution of cord blood stem cell transplant recipients increase the risk of infectious complications. We retrospectively reviewed patients who underwent cord blood stem cell transplantation at Roswell Park Cancer Institute for hematological malignancies and who survived beyond day 100 for late infectious events. Among 15 patients who were included in the study, there were 18 episodes of bacteremia, 5 cases of bacterial pneumonia, 9 viral, 4 fungal, and 1 nontuberculous mycobacterial infection. Overall mortality was 60%, with infections contributing in 44% of cases. In conclusion, survival beyond day 100 following cord bloodstem cell transplantation is associated with a considerable risk of infections in our single center experience.

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References

  1. De Pauw B, Walsh TJ, Donnelly JP, Stevens DA, Edwards JE, Calandra T et al (2008) Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group. Clin Infect Dis 46(12):1813–1821. doi:10.1086/588660

    Article  PubMed  Google Scholar 

  2. Ljungman P, Griffiths P, Paya C (2002) Definitions of cytomegalovirus infection and disease in transplant recipients. Clin Infect Dis 34(8):1094–1097. doi:10.1086/339329

    Article  PubMed  Google Scholar 

  3. Hamza NS, Lisgaris M, Yadavalli G, Nadeau L, Fox R, Fu P et al (2004) Kinetics of myeloid and lymphocyte recovery and infectious complications after unrelated umbilical cord blood versus HLA-matched unrelated donor allogeneic transplantation in adults. Br J Haematol 124(4):488–498. doi:10.1046/j.1365-2141.2003.04792.x

    Article  PubMed  Google Scholar 

  4. Parody R, Martino R, Rovira M, Vazquez L, Vazquez MJ, de la Camara R et al (2006) Severe infections after unrelated donor allogeneic hematopoietic stem cell transplantation in adults: comparison of cord blood transplantation with peripheral blood and bone marrow transplantation. Biol Blood Marrow Transplant 12(7):734–748. doi:10.1016/j.bbmt.2006.03.007

    Article  PubMed  Google Scholar 

  5. Saavedra S, Sanz GF, Jarque I, Moscardo F, Jimenez C, Lorenzo I et al (2002) Early infections in adult patients undergoing unrelated donor cord blood transplantation. Bone Marrow Transplant 30(12):937–943. doi:10.1038/sj.bmt.1703764

    Article  CAS  PubMed  Google Scholar 

  6. Safdar A, Rodriguez GH, De Lima MJ, Petropoulos D, Chemaly RF, Worth LL et al (2007) Infections in 100 cord blood transplantations: spectrum of early and late posttransplant infections in adult and pediatric patients 1996–2005. Medicine (Baltimore) 86(6):324–333. doi:10.1097/MD.0b013e31815c52b0

    Article  Google Scholar 

  7. Boeckh M, Leisenring W, Riddell SR, Bowden RA, Huang ML, Myerson D et al (2003) Late cytomegalovirus disease and mortality in recipients of allogeneic hematopoietic stem cell transplants: importance of viral load and T-cell immunity. Blood 101(2):407–414. doi:10.1182/blood-2002-03-0993

    Article  CAS  PubMed  Google Scholar 

  8. Marr KA, Carter RA, Boeckh M, Martin P, Corey L (2002) Invasive aspergillosis in allogeneic stem cell transplant recipients: changes in epidemiology and risk factors. Blood 100(13):4358–4366. doi:10.1182/blood-2002-05-1496

    Article  CAS  PubMed  Google Scholar 

  9. Niehues T, Rocha V, Filipovich AH, Chan KW, Porcher R, Michel G et al (2001) Factors affecting lymphocyte subset reconstitution after either related or unrelated cord blood transplantation in children—a Eurocord analysis. Br J Haematol 114(1):42–48. doi:10.1046/j.1365-2141.2001.02900.x

    Article  CAS  PubMed  Google Scholar 

  10. Thomson BG, Robertson KA, Gowan D, Heilman D, Broxmeyer HE, Emanuel D et al (2000) Analysis of engraftment, graft-versus-host disease, and immune recovery following unrelated donor cord blood transplantation. Blood 96(8):2703–2711

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Medicine, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, 14263, USA

    N. G. Almyroudis, J. Fabian, T. Hahn, B. H. Segal, M. Wetzler & P. L. McCarthy Jr.

  2. Department of Immunology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, 14263, USA

    B. H. Segal

  3. SUNY at Buffalo, Division of Infectious Diseases, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, 14263, USA

    N. G. Almyroudis

Authors
  1. N. G. Almyroudis
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  2. J. Fabian
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  3. T. Hahn
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  4. B. H. Segal
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  5. M. Wetzler
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  6. P. L. McCarthy Jr.
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Correspondence to N. G. Almyroudis.

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Almyroudis, N.G., Fabian, J., Hahn, T. et al. Late infectious complications after cord blood stem cell transplantation. Eur J Clin Microbiol Infect Dis 28, 1405–1408 (2009). https://doi.org/10.1007/s10096-009-0789-2

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  • DOI: https://doi.org/10.1007/s10096-009-0789-2

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