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Linkage of a commoner form of recessive amyotrophic lateral sclerosis to chromosome 15q15-q22 markers

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ABSTRACT

Autosomal recessive familial amyotrophic lateral sclerosis (RFALS) is a rare form of ALS that usually presents at an early age with slow progression of symptoms. RFALS is clinically and genetically heterogeneous and the locus of RFALS type 3 was mapped to 2q33 (ALS2) in a single family. We now report linkage of a more-common form of RFALS to chromosome 15q15-q22 markers (ALS5) and show further genetic locus heterogeneity in RFALS. ALS5 is the locus for most families with RFALS and appears to be present in both North African and European populations.

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Authors and Affiliations

  1. Northwestern University Medical School, Tarry Building Room 13-715, 300 E. Superior Street, Chicago, Illinois 60611, USA Tel: (312) 503 4737; Fax: (312) 908 0865 e-mail: A. Hentati: afif@nwu.edu, T. Siddique: t-siddique@nwu.edu, , , , , , US

    Afif Hentati, Karim Ouahchi, Deepak Nijhawan, Y. Yang, W.-Y. Hung & T. Siddique

  2. Duke University Medical Center, Durham, North Carolina, USA, , , , , , US

    Margaret A. Pericak-Vance & Jackie Rimmler

  3. Dow Medical College, Civil Hospital, Karachi, Pakistan, , , , , , PK

    Arsalan Ahmad & Akhtar Ahmed

  4. Friedrich-Baur Institut, Klinikum Innenstadt-Ludwig Maximilians Universitat, Munich, Germany, , , , , , DE

    Beate Schlotter

  5. Institut National de Neurology, La Rabta 1007, Tunis, Tunisia, , , , ,

    Mongi Ben Hamida & Fayçal Hentati

Authors
  1. Afif Hentati
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  2. Karim Ouahchi
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  3. Margaret A. Pericak-Vance
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  4. Deepak Nijhawan
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  5. Arsalan Ahmad
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  6. Y. Yang
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  7. Jackie Rimmler
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  8. W.-Y. Hung
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  9. Beate Schlotter
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  10. Akhtar Ahmed
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  11. Mongi Ben Hamida
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  12. Fayçal Hentati
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  13. T. Siddique
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Additional information

Received: July 22, 1998 / Accepted: September 18, 1998 / Published online: December 18, 1998

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Hentati, A., Ouahchi, K., Pericak-Vance, M. et al. Linkage of a commoner form of recessive amyotrophic lateral sclerosis to chromosome 15q15-q22 markers. Neurogenetics 2, 55–60 (1998). https://doi.org/10.1007/s100480050052

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  • DOI: https://doi.org/10.1007/s100480050052

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