Abstract
We describe a rare case of multinodular cerebral neuroepithelial tumor with ependymal differentiation. A 65-year-old man experienced loss of consciousness with an obscure episode of seizure attack. Magnetic resonance images disclosed a lesion located in the left temporal lobe and the insular cortex. The tumor was partially removed. Histologically, the tumor showed infiltrating multinodular tumor nodules in the cerebrum. Each nodule was well demarcated and composed of clear cells with perinuclear halos, intermingled fibrillary cells, and poorly differentiated neuroepithelial cells with mitotic activity. Immunohistochemically, clear cells showed dot-like positivity for epithelial membrane antigen. Fibrillary cells were positive for vimentin and nestin, whereas only a few glial fibrillary acidic protein-immunopositive cells were seen. We conclude that this tumor, being microscopically characterized by multinodular tumor nodules, was a high-grade neuroepithelial tumor with ependymal differentiation.
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References
Louis DN, Ohgaki H, Otmar D et al (2007) WHO classification of tumors of the central nervous system, 4th edn. IARC Press, Lyon
Kawano N, Yasui Y, Utsuki S, Oka H et al (2004) Light microscopic demonstration of the microlumen of ependymoma: a study of the usefulness of antigen retrieval for epithelial membrane antigen (EMA) immunostaining. Brain Tumor Pathol 21:17–21
Figarella BD, Gambarelli D, Dollo C et al (1991) Infratentorial ependymomas of childhood. Correlation between histological features, immunohistological phenotype, silver nucleolar organizer region staining values and post-operative survival in 16 cases. Acta Neuropathol (Berl) 82(3):208–216
Almqvist PM, Mah R, Lendahl U et al (2002) Immunohistochemical detection of nestin in pediatric brain tumors. J Histochem Cytochem 50:147–158
Ishizawa K, Komori T, Shimada S, Hirose T (2008) Olig2 and CD99 are useful negative markers for the diagnosis of brain tumors. Clin Neuropathol 27(3):118–128
Kimura T, Budka H, Soler FS (1986) An immunocytochemical comparison of the glia-associated proteins glial fibrillary acidic protein (GFAP) and S-100 protein (S100P) in human brain tumors. Clin Neuropathol 5:21–27
Gullota F, Schindler F, Schmultzler R et al (1985) GFAP in brain tumor diagnosis: possibilities and limitations. Pathol Res Pract 180:54–60
Kurt E, Zheng PP, Hop WC et al (2006) Identification of relevant prognostic histopathologic features in 69 intracranial ependymomas, excluding myxopapillary ependymomas and subependymomas. Cancer (Phila) 106:388–395
Engelhard HH, Duncan HA, Del Canto M (1997) Molecular characterization of glioblastoma cell differentiation. Neurosurgery 41(4):886–896
Miyazawa T, Hirose T, Nakanishi K et al (2007) Supratentorial ectopic cortical ependymoma occurring with intratumoral hemorrhage. Brain Tumor Pathol 24(1):35–40
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This work was supported in part by a Nagasaki University President’s Fund Grant.
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Kamada, K., Tanaka, Y., Matsuo, T. et al. A case of multinodular high-grade neuroepithelial tumor with ependymal differentiation. Brain Tumor Pathol 28, 253–257 (2011). https://doi.org/10.1007/s10014-011-0032-6
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DOI: https://doi.org/10.1007/s10014-011-0032-6