Skip to main content

Advertisement

SpringerLink
Log in

Clinicopathological and immunohistochemical study of 20 choroid plexus tumors: their histological diversity and the expression of markers useful for differentiation from metastatic cancer

  • Original Article
  • Published:
Brain Tumor Pathology Aims and scope Submit manuscript

Abstract

The aim of this study was to summarize the clinicopathological features and the histological diversity of choroid plexus tumors and to examine the expression of immunohistochemical markers that are useful for their differentiation from metastatic cancer. Twenty cases were collected, including 11 choroid plexus papillomas, 5 choroid plexus adenomas, 1 atypical choroid plexus papilloma, and 3 choroid plexus carcinomas. The choroid plexus papillomas showed various parenchymal and stromal changes: focal solid growth, oncocytic alterations, melanin deposition, calcification, ossification, and xanthogranulomatous reactions. The choroid plexus tumors showed the following cytokeratin (CK) 7 and 20 staining patterns: CK7(+)/CK20(+) (11/19 cases), CK7(+)/CK20(−) (7/19 cases), CK7(−)/CK20(−) (1/19 cases), and CK7(−)/CK20(+) (0/19 cases). Positivity for CK5/6 and thyroid transcription factor-1 was found in 3 of 18 and 1 of 19 cases, respectively. All cases were negative for the estrogen receptor (0/18 cases). The choroid plexus tumors showed various CK7/CK20 staining patterns, and the staining of CK7 and CK20 in most CK7(+)/CK20(+) and CK7(+)/CK20(−) cases was focal, in contrast to that observed in carcinomas. Therefore, nondiffuse staining of CK, rather than the CK7/CK20 panel itself, is important for discriminating between a choroid plexus tumor and metastatic cancer.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Louis DN, Ohgaki H, Wiestler OD et al (2007) WHO classification of tumours of the central nervous system. IARC Press, Lyon

    Google Scholar 

  2. Rembao-Bojórquez D, Vega R, Bermúdez-Maldonado L et al (2007) Choroid plexus acinar adenoma: a case report. J Neurooncol 83:191–197

    Article  PubMed  Google Scholar 

  3. Eljamel MS, Jeffreys RV (1990) Mucous-secreting choroid plexus adenoma: case report and review of the literature. Neuropediatrics 21:55–56

    Article  PubMed  CAS  Google Scholar 

  4. Duckett S, Osterholm J, Schaefer D et al (1991) Ossified mucin-secreting choroid plexus adenoma: case report. Neurosurgery 29:130–132

    Article  PubMed  CAS  Google Scholar 

  5. Aquilina K, Nanra JS, Allcutt DA, Farrell M (2005) Choroid plexus adenoma: case report and review of the literature. Childs Nerv Syst 21:410–415

    Article  PubMed  Google Scholar 

  6. Diengdoh JV, Shaw MD (1993) Oncocytic variant of choroid plexus papilloma. Evolution from benign to malignant “oncocytoma”. Cancer (Phila) 71:855–858

    Article  CAS  Google Scholar 

  7. Shintaku M, Nitta T, Matsubayashi K, Okamoto S (2008) Ossifying choroid plexus papilloma recurring with features of atypical papilloma. Neuropathology 28:160–164

    Article  PubMed  Google Scholar 

  8. Kamar FG, Posner JB (2010) Brain metastases. Semin Neurol 30:217–235

    Article  PubMed  Google Scholar 

  9. Gril B, Evans L, Palmieri D, Steeg PS (2010) Translational research in brain metastasis is identifying molecular pathways that may lead to the development of new therapeutic strategies. Eur J Cancer 46:1204–1210

    Article  PubMed  CAS  Google Scholar 

  10. Loy TS, Calaluce RD (1994) Utility of cytokeratin immunostaining in separating pulmonary adenocarcinomas from colonic adenocarcinomas. Am J Clin Pathol 102:764–767

    PubMed  CAS  Google Scholar 

  11. Loy TS, Calaluce RD, Keeney GL (1996) Cytokeratin immunostaining in differentiating primary ovarian carcinoma from metastatic colonic adenocarcinoma. Mod Pathol 9:1040–1044

    PubMed  CAS  Google Scholar 

  12. Perry A, Parisi JE, Kurtin PJ (1997) Metastatic adenocarcinoma to the brain: an immunohistochemical approach. Hum Pathol 28:938–943

    Article  PubMed  CAS  Google Scholar 

  13. Tot T (2002) Cytokeratins 20 and 7 as biomarkers: usefulness in discriminating primary from metastatic adenocarcinoma. Eur J Cancer 38:758–763

    Article  PubMed  CAS  Google Scholar 

  14. Gyure KA, Morrison AL (2000) Cytokeratin 7 and 20 expression in choroid plexus tumors: utility in differentiating these neoplasms from metastatic carcinomas. Mod Pathol 13:638–643

    Article  PubMed  CAS  Google Scholar 

  15. Gaudio RM, Tacconi L, Rossi ML (1998) Pathology of choroid plexus papillomas: a review. Clin Neurol Neurosurg 100:165–186

    Article  PubMed  CAS  Google Scholar 

  16. Wolff JE, Sajedi M, Brant R et al (2002) Choroid plexus tumours. Br J Cancer 87:1086–1091

    Article  PubMed  CAS  Google Scholar 

  17. Jeibmann A, Hasselblatt M, Gerss J et al (2006) Prognostic implications of atypical histologic features in choroid plexus papilloma. J Neuropathol Exp Neurol 65:1069–1073

    Article  PubMed  Google Scholar 

  18. Wrede B, Hasselblatt M, Peters O et al (2009) Atypical choroid plexus papilloma: clinical experience in the CPT-SIOP-2000 study. J Neurooncol 95:383–392

    Article  PubMed  CAS  Google Scholar 

  19. Jeibmann A, Wrede B, Peters O et al (2007) Malignant progression in choroid plexus papillomas. J Neurosurg 107:199–202

    PubMed  Google Scholar 

  20. Wasita B, Sakamoto M, Mizushima M et al (2010) Choroid plexus metastasis from papillary thyroid carcinoma presenting with intraventricular hemorrhage: case report. Neurosurgery 66:E1213–E1214

    Article  PubMed  Google Scholar 

  21. Yatabe Y, Mitsudomi T, Takahashi T (2002) TTF-1 expression in pulmonary adenocarcinomas. Am J Surg Pathol 26:767–773

    Article  PubMed  Google Scholar 

  22. Zafrani B, Aubriot MH, Mouret E et al (2000) High sensitivity and specificity of immunohistochemistry for the detection of hormone receptors in breast carcinoma: comparison with biochemical determination in a prospective study of 793 cases. Histopathology (Oxf) 37:536–545

    Article  CAS  Google Scholar 

  23. Haupt B, Ro JY, Schwartz MR (2010) Basal-like breast carcinoma: a phenotypically distinct entity. Arch Pathol Lab Med 134:130–133

    PubMed  Google Scholar 

  24. Tang P, Skinner KA, Hicks DG (2009) Molecular classification of breast carcinomas by immunohistochemical analysis: are we ready? Diagn Mol Pathol 18:125–132

    Article  PubMed  CAS  Google Scholar 

  25. Wolburg H, Paulus W (2010) Choroid plexus: biology and pathology. Acta Neuropathol 119:75–88

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

We thank the following institutions for consulting our department about choroid plexus tumors: Department of Pathology, Yokkaichi Municipal Hospital; Department of Pathology, Hitachi General Hospital; Department of Human Pathology, Wakayama Medical University; Department of Pathology, Hamamatsu University School of Medicine; Department of Human Pathology, Juntendo University School of Medicine; Division of Diagnostic Pathology, Keio University Hospital; Department of Pathology, NTT Medical Center, Tokyo; Department of Neurosurgery, Yamagata University School of Medicine; Department of Neurosurgery, University of Occupational and Environmental Health; Department of Pathology, Japanese Red Cross Society, Himeji Hospital; Department of Neurosurgery, Hirosaki University; Department of Pathology, University of Miyazaki; and Department of Neuropathology, Institute of Neurology, Huashan Hospital, Fudan University.

Author information

Authors and Affiliations

  1. Department of Human Pathology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan

    Hayato Ikota, Yuko Tanaka, Hideaki Yokoo & Yoichi Nakazato

Authors
  1. Hayato Ikota
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yuko Tanaka
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hideaki Yokoo
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yoichi Nakazato
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hayato Ikota.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ikota, H., Tanaka, Y., Yokoo, H. et al. Clinicopathological and immunohistochemical study of 20 choroid plexus tumors: their histological diversity and the expression of markers useful for differentiation from metastatic cancer. Brain Tumor Pathol 28, 215–221 (2011). https://doi.org/10.1007/s10014-011-0024-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10014-011-0024-6

Keywords

Search

Navigation