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Synthesis of water-soluble ruthenium porphyrins as DNA cleavers and potential cytotoxic agents

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Abstract

 Three new water-soluble ruthenium porphyrin complexes have been prepared and characterized, one with a cationic ligand, Ru(TMPyP), and two others with anionic ligands, Ru(p–COOH-PP) and Ru(TPPS). These different complexes and their manganese and iron analogues were tested in vivo as potential antitumor agents with mice bearing P388 leukemia cells, but these complexes have no significant antitumor activity. The nuclease activity of Ru(TMPyP) and Ru(p–COOH-PP) was evaluated on supercoiled plasmid DNA after activation by a reducing agent (ascorbate) in the presence of air or by potassium monopersulfate. No significant activity was evidenced for these ruthenium complexes, in contrast with the already known nuclease activity of the manganese and iron derivatives of TMPyP.

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Authors and Affiliations

  1. Laboratoire de Chimie de Coordination du CNRS, 205 Route de Narbonne, F-31077 Toulouse cedex 4, France, , , , , , FR

    Markus Hartmann, Anne Robert, Victor Duarte & B. Meunier

  2. Anorganisch-Chemisches Institut, Universität Heidelberg, Im Neuenheimer Feld 270, D-69120 Heidelberg, Germany, , , , , , DE

    Bernhard K. Keppler

Authors
  1. Markus Hartmann
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  2. Anne Robert
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  3. Victor Duarte
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  4. Bernhard K. Keppler
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  5. B. Meunier
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Received: 15 November 1996 / Accepted: 7 April 1997

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Hartmann, M., Robert, A., Duarte, V. et al. Synthesis of water-soluble ruthenium porphyrins as DNA cleavers and potential cytotoxic agents. JBIC 2, 427–432 (1997). https://doi.org/10.1007/s007750050153

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  • DOI: https://doi.org/10.1007/s007750050153

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