Abstract
Dynamic nuclear polarization (DNP) is used to enhance signals in NMR and MRI experiments. During these experiments microwave (MW) irradiation mediates transfer of spin polarization from unpaired electrons to their neighboring nuclei. Solid state DNP is typically applied to samples containing high concentrations (i.e. 10–40 mM) of stable radicals that are dissolved in glass forming solvents together with molecules of interest. Three DNP mechanisms can be responsible for enhancing the NMR signals: the solid effect (SE), the cross effect (CE), and thermal mixing (TM). Recently, numerical simulations were performed to describe the SE and CE mechanisms in model systems composed of several nuclei and one or two electrons. It was shown that the presence of core nuclei, close to DNP active electrons, can result in a decrease of the nuclear polarization, due to broadening of the double quantum (DQ) and zero quantum (ZQ) spectra. In this publication we consider samples with high radical concentrations, exhibiting broad inhomogeneous EPR line-shapes and slow electron cross-relaxation rates, where the TM mechanism is not the main source for the signal enhancements. In this case most of the electrons in the sample are not affected by the MW field applied at a discrete frequency. Numerical simulations are performed on spin systems composed of several electrons and nuclei in an effort to examine the role of the DNP inactive electrons. Here we show that these electrons also broaden the DQ and ZQ spectra, but that they hardly cause any loss to the DNP enhanced nuclear polarization due to their spin-lattice relaxation mechanism. Their presence can also prevent some of the polarization losses due to the core nuclei.
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Acknowledgments
This work was supported by the German-Israeli Project Cooperation of the DFG through a special allotment by the Ministry of Education and Research (BMBF) of the Federal Republic of Germany. It was made possible in part by the historic generosity of the Harold Perlman Family. S.V. holds the Joseph and Marian Robbins Professorial Chair in Chemistry.
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Appendix: Probability of Nearest Electron Neighbors
Appendix: Probability of Nearest Electron Neighbors
Here we calculate the microscopic probability of finding electrons within a given distance from one another, or with a minimal given dipolar interaction strength. We consider N randomly distributed and immobilized electrons in a sample of volume V [Å3], resulting in an electron concentration (in [mM]) of \(C=\frac{N}{\sigma V}, \) with σ ≃ 6.02 × 10−7 [mM−1 Å−3]. Assuming that each electron is a point in space, the probability of each electron b ≠ a to be within a distance r ab ≤ r l ≪ V −1/3 from a single electron a is given by v/V, where \(v=\frac{4}{3}\pi r_{l}^{3}\) is a volume with electron a in its center. Alternatively, we can evaluate the probability of finding a dipolar interaction strength of |D ab | ≥ D l . In this case we get for v:
with \(D_{e}=\frac{\mu_{0}}{8\pi\hbar}g_{a}g_{b}\beta_{e}^{2}. \) The probability that there are n ≥ 1 such b electrons in a volume v ≪ V is given by
were F n=0 is the probability that there are no electrons in the volume v. In the last step we considered the limit of \(V\rightarrow\infty. \) The probability of having only one b electron in the volume v is given by
Next, we consider a minimal distance r 0 between each electron pair. Assuming that the electrons take a negligible portion of the total volume, \(N(\frac{4}{3}\pi r_{0}^{3})\ll V, \) the radial distribution remains as in Eqs. 21 and 22, but with \(v=\frac{4}{3}\pi(r_{l}^{3}-r_{0}^{3}). \) To the best of our knowledge there is no simple solution to the dipolar interaction distribution in this case. Some insight can never the less be obtained by considering the value of D e r −3 ≥ D e r −3 l , since 0 ≤ D ab ≤ 2D e r −3. Equation 20 can still be used if \(\frac{16}{9\sqrt{3}}\frac{D_{e}}{D_{l}}\gg\frac{4}{3}\pi r_{0}^{3}.\)
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Hovav, Y., Levinkron, O., Feintuch, A. et al. Theoretical Aspects of Dynamic Nuclear Polarization in the Solid State: The Influence of High Radical Concentrations on the Solid Effect and Cross Effect Mechanisms. Appl Magn Reson 43, 21–41 (2012). https://doi.org/10.1007/s00723-012-0359-0
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DOI: https://doi.org/10.1007/s00723-012-0359-0