Abstract
A highly divergent human papillomavirus, named HPV-CH2, was identified in fecal samples from children with diarrhea in China by 454 high-throughput sequencing. Here, we report the complete genome sequence and genetic organization of the virus. The full-length nucleotide sequence of HPV-CH2 shares the highest sequence similarity with HPV-156, with 72 % nucleotide sequence identity. The L1 gene of the HPV-CH2 shared <70 % nucleotide identity with previously reported HPVs, suggesting HPV-CH2 as a new type of papillomavirus. Phylogenetic analysis revealed that the HPV-CH2 belongs to the genus Gammapapillomavirus. No HPV-CH2 was detected by PCR in samples from children with both gastroenteritis and respiratory infection.
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Acknowledgments
This work was supported by the National Natural Science Foundation of China (Grant No. 81290345) and by the China Mega-Project for Infectious Disease (Grant No. 2011ZX10004).
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The authors declare that they have no competing interests.
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Yu, Jm., Zhao, G., Ao, Yy. et al. Complete genome sequence of a novel human papillomavirus identified by metagenomic analysis from a child with diarrhea in China. Arch Virol 160, 549–552 (2015). https://doi.org/10.1007/s00705-014-2252-7
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DOI: https://doi.org/10.1007/s00705-014-2252-7