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Characterization of a genetic and antigenic variant of avian paramyxovirus 6 isolated from a migratory wild bird, the red-necked stint (Calidris ruficollis)

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Abstract

A hemagglutinating virus (8KS0813) was isolated from a red-necked stint. Hemagglutination inhibition and neutralization tests indicated that 8KS0813 was antigenically related to a prototype strain, APMV-6/duck/Hong Kong/18/199/77, but with an 8- and 16-fold difference, respectively, in their titers. The full genome sequence of 8KS0813 showed 98.6 % nucleotide sequence identity to that of APMV-6/duck/Italy/4524-2/07, which has been reported to belong to an APMV-6 subgroup, and showed less similarity to that of the prototype strain (70.6 % similarity). The growth of 8KS0813 and the prototype strain in four different cell cultures was greatly enhanced by adding trypsin. Interestingly, this virus induced syncytia only in Vero cells. 8KS0813 was identified as APMV-6/red-necked stint/Japan/8KS0813/08, but it is antigenically and genetically distinguishable from the prototype strain, suggesting that variant APMV-6 is circulating in migratory birds.

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Acknowledgments

We thank Dr. Shigeru Morikawa, National Institute of Infectious Disease, for invaluable suggestions in analysis of the sample. We are also grateful for the technical support of Sachiko Matsuda, Obihiro University of Agriculture and Veterinary Medicine, and Miho Nishimura, Fukuoka University. This work was partially supported by grants from the Program of Founding Research Centers for Emerging and Reemerging Infectious Diseases and by a Grant-in-Aid for Exploratory Research (19659115) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan. This work was also partially supported by the US National Institute of Allergy and Infectious Diseases (NIAID contracts HHSN266200700009C and HHSN266200700007C).

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Author notes

  1. Tetsuya Mizutani

    Present address: Tokyo University of Agriculture and Technology, Saiwaicho, Fuchu, Tokyo, 183-8509, Japan

  2. Jonathan Runstadler

    Present address: Massachusetts Institute of Technology, Cambridge, MA, 02139, USA

Authors and Affiliations

  1. Research Center for Animal Hygiene and Food Safety, Obihiro University of Agriculture and Veterinary Medicine, 2-11 Inada, Obihiro, Hokkaido, 080-8555, Japan

    Vuong Nghia Bui, Tung Hoang Nguyen, Dai Quang Trinh, Sanaa S. A. Awad, Germaine L. Minoungou, Haruko Ogawa & Kunitoshi Imai

  2. Virology 1, National Institute of Infectious Diseases, Gakuen 4-7-1, Musashimurayama, Tokyo, 208-0011, Japan

    Tetsuya Mizutani

  3. National Institute of Animal Health, Tsukuba, Ibaraki, 305-0856, Japan

    Yu Yamamoto & Kikuyasu Nakamura

  4. Institute for Raptor Biomedicine, Kushiro, Hokkaido, 084-0922, Japan

    Keisuke Saito & Yukiko Watanabe

  5. Institute of Arctic Biology, Biology and Wildlife Department, University of Alaska-Fairbanks (UAF), Fairbanks, AK, 99775, USA

    Jonathan Runstadler & Falk Huettmann

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  1. Vuong Nghia Bui
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Corresponding author

Correspondence to Kunitoshi Imai.

Electronic supplementary material

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705_2014_2162_MOESM1_ESM.tif

Supplementary Fig. S1 Electron micrograph of 8KS0813 particles stained with 2% phosphotungstic acid (pH 6.5). (TIFF 248 kb)

Supplementary material 2 (DOC 48 kb)

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Bui, V.N., Mizutani, T., Nguyen, T.H. et al. Characterization of a genetic and antigenic variant of avian paramyxovirus 6 isolated from a migratory wild bird, the red-necked stint (Calidris ruficollis). Arch Virol 159, 3101–3105 (2014). https://doi.org/10.1007/s00705-014-2162-8

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  • DOI: https://doi.org/10.1007/s00705-014-2162-8

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