Abstract
Mumps is a vaccine-preventable disease that usually occurs as a self-limiting parotitis, but it can also lead to several life-threatening complications, including pancreatitis, meningitis, and encephalitis. The molecular epidemiology of the virus is poorly understood. The present study describes an outbreak of mumps virus infection in Punjab, India. The etiology was confirmed by serology and RNA detection to be mumps virus in 72 % of the cases and 50 % of contacts. This study, for the first time, revealed the mumps virus genotypes circulating in the Indian subcontinent as subtype G2 of genotype G.
This is a preview of subscription content, log in via an institution to check access.
References
Dayan GH, Quinlisk MP, Parker AA, Barskey AE, Harris ML, Schwartz JM, Hunt K, Finley CG, Leschinsky DP, O’Keefe AL, Clayton J, Kightlinger LK, Dietle EG, Berg J, Kenyon CL, Goldstein ST, Stokley SK, Redd SB, Rota PA, Rota J, Bi D, Roush SW, Bridges CB, Santibanez TA, Parashar U, Bellini WJ, Seward JF (2008) Recent resurgence of mumps in the United States. N Engl J Med 358:1580–1589
Echevarria JE, Castellanos A, Sanz JC, Perez C, Palacios G, Martinez de Aragon MV, Pena Rey I, Mosquera M, de Ory F, Royuela E (2010) Circulation of mumps virus genotypes in Spain from 1996 to 2007. J Clin Microbiol 48:1245–1254
Geeta MG, Kumar PK (2004) Mumps–need for urgent action. Indian Pediatr 41:1181–1182
Ghatage ST, Kakade GM (2007) An outbreak of mumps meningoencephalitis in Sangli district. Indian Pediatr 44:235
Guidelines for the prevention and control of mumps outbreaks in Canada. http://www.phac-aspc.gc.ca/publicat/ccdr-rmtc/10pdf/36s1-eng.pdf
Hatchette TF, Mahony JB, Chong S, LeBlanc JJ (2009) Difficulty with mumps diagnosis: what is the contribution of mumps mimickers? J Clin Virol 46:381–383
Inou Y, Nakayama T, Yoshida N, Uejima H, Yuri K, Kamada M, Kumagai T, Sakiyama H, Miyata A, Ochiai H, Ihara T, Okafuji T, Okafuji T, Nagai T, Suzuki E, Shimomura K, Ito Y, Miyazaki C (2004) Molecular epidemiology of mumps virus in Japan and proposal of two new genotypes. J Med Virol 73:97–104
Jin L, Beard S, Brown DW (1999) Genetic heterogeneity of mumps virus in the United Kingdom: identification of two new genotypes. J Infect Dis 180:829–833
Jin L, Beard S, Hale A, Knowles W, Brown DW (2000) The genomic sequence of a contemporary wild-type mumps virus strain. Virus Res 70:75–83
Jin L, Rima B, Brown D, Orvell C, Tecle T, Afzal M, Uchida K, Nakayama T, Song JW, Kang C, Rota PA, Xu W, Featherstone D (2005) Proposal for genetic characterisation of wild-type mumps strains: preliminary standardisation of the nomenclature. Arch Virol 150:1903–1909
Palacios G, Jabado O, Cisterna D, de Ory F, Renwick N, Echevarria JE, Castellanos A, Mosquera M, Freire MC, Campos RH, Lipkin WI (2005) Molecular identification of mumps virus genotypes from clinical samples: standardized method of analysis. J Clin Microbiol 43:1869–1878
Paterson RG, Lamb RA (1990) RNA editing by G-nucleotide insertion in mumps virus P-gene mRNA transcripts. J Virol 64:4137–4145
Takeuchi K, Tanabayashi K, Hishiyama M, Yamada A (1996) The mumps virus SH protein is a membrane protein and not essential for virus growth. Virology 225:156–162
WHO (2005) Global status of mumps immunization and surveillance. Wkly Epidemiol Rec 80: 418–424
Acknowledgement
We would like to acknowledge the technical support of Mrs. Ragini and Vikas Verma for virus isolation, and Mr. Vikas Kumar for serological tests.
Conflict of interest
The authors declare that they have no competing interests.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Mishra, B., Pujhari, S.K., Dhiman, V. et al. Genotyping and subtyping of mumps virus isolates from the Indian subcontinent. Arch Virol 158, 2359–2363 (2013). https://doi.org/10.1007/s00705-013-1717-4
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00705-013-1717-4