Summary.
Currently circulating influenza B viruses can be divided into two antigenically and genetically distinct lineages referred to by their respective prototype strains, B/Yamagata/16/88 and B/Victoria/2/87, based on amino acid differences in the hemagglutinin surface glycoprotein. During May and July 2005, clinical specimens from two early season influenza B outbreaks in Arizona and southeastern Nepal were subjected to antigenic (hemagglutinin inhibition) and nucleotide sequence analysis of hemagglutinin (HA1), neuraminidase (NA), and NB genes. All isolates exhibited little reactivity with the B/Shanghai/361/2002 (B/Yamagata-like) vaccine strain and significantly reduced reactivity with the previous 2003/04 B/Hong Kong/330/2001 (B/Victoria-like) vaccine strain. The majority of isolates were antigenically similar to B/Hawaii/33/2004, a B/Victoria-like reference strain. Sequence analysis indicated that 33 of 34 isolates contained B/Victoria-like HA and B/Yamagata-like NA and NB proteins. Thus, these outbreak isolates are both antigenically and genetically distinct from the current Northern Hemisphere vaccine virus strain as well as the previous 2003–04 B/Hong Kong/330/2001 (B/Victoria lineage) vaccine virus strain but are genetically similar to B/Malaysia/2506/2004, the vaccine strain proposed for the coming seasons in the Northern and Southern Hemispheres. Since these influenza B outbreaks occurred in two very distant geographical locations, these viruses may continue to circulate during the 2006 season, underscoring the importance of rapid molecular monitoring of HA, NA and NB for drift and reassortment.
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References
XS Chi TV Bolar P Zhao R Rappaport SM Cheng (2003) ArticleTitleCocirculation and evolution of two lineages of influenza B viruses in Europe and Israel in the 2001–2002 season J Clin Microbiol 41 5770–5773 Occurrence Handle14662979 Occurrence Handle1:CAS:528:DC%2BD2cXjtF2gtQ%3D%3D Occurrence Handle10.1128/JCM.41.12.5770-5773.2003
LT Daum LC Canas CB Smith A Klimov WB Huff WJ Barnes KL Lohman (2002) ArticleTitleGenetic and Antigenic analysis for the first a/New Caledonia20/99-like H1N1 influenza isolates reported in the Americas Emerg Infect Dis 8 408–412 Occurrence Handle11971776 Occurrence Handle1:CAS:528:DC%2BD38XjtlSlsbY%3D Occurrence Handle10.3201/eid0804.010311
LT Daum MW Shaw AL Klimov LC Canas EA Macias D Niemeyer JP Chambers R Renthal SK Shrestha RP Acharya SP Huzhar N Rimal KS Myint P Gould (2005) ArticleTitleInfluenza A (H3N2) outbreak, Nepal Emerg Infect Dis 11 1186–1191 Occurrence Handle16102305
AP Kendel MS Pereura J Skehel (1982) Concepts and procedures for laboratory based influenza surveillance World Health Organization Geneva
M Krystal JF Young P Palese IA Wilson JJ Skehel DC Wiley (1983) ArticleTitleSequential mutations in hemagglutinins of influenza B virus isolates. Definition of antigenic domains Proc Natl Acad Sci USA 80 4527–4531 Occurrence Handle6192436 Occurrence Handle1:CAS:528:DyaL3sXltlOru78%3D Occurrence Handle10.1073/pnas.80.14.4527
JA McCullers S Takehiko AR Iverson (2004) ArticleTitleMultiple genotypes of influenza B virus circulated between 1979 and 2003 J Virol 78 12817–12828 Occurrence Handle15542634 Occurrence Handle1:CAS:528:DC%2BD2cXhtVaqtbvK Occurrence Handle10.1128/JVI.78.23.12817-12828.2004
JA McCullers GC Wang S He RG Webster (1999) ArticleTitleReassortment and insertion–deletion are strategies for the evolution of influenza B viruses in nature J Virol 73 7343–7348 Occurrence Handle10438823 Occurrence Handle1:CAS:528:DyaK1MXltlKhsbY%3D
Morbidity and Mortality Weekly Report (MMWR) (2005) Update: Influenza activity – United States, 2004–05 season 54: 328–331
Morbidity and Mortality Weekly Report (MMWR) (2005) Update: Influenza activity – United States and worldwide, May 22–September 3, 2005, and 2005–06 season vaccination recommendations
S Puzelli F Frezza C Fabiani A Filippo L Campitelli YP Lin V Gregory M Bennett P DAraro C Campello P Crovari A Hay I Donatelli (2004) ArticleTitleChanges in the hemag- glutinins and neuraminidase of human influenza B viruses isolated in Italy during the 2001–2, 2002–3, and 2003–4 seasons J Med Virol 74 629–640 Occurrence Handle15484280 Occurrence Handle1:CAS:528:DC%2BD2cXhtVahs7fJ Occurrence Handle10.1002/jmv.20225
PA Rota TR Wallis MW Harmon JS Rota AP Kendal K Nerome (1990) ArticleTitleCocirculation of two distinct evolutionary lineages of influenza type B virus since 1983 Virology 175 59–68 Occurrence Handle2309452 Occurrence Handle1:CAS:528:DyaK3cXktVejsLk%3D Occurrence Handle10.1016/0042-6822(90)90186-U
MW Shaw PW Choppin RA Lamb (1983) ArticleTitleA previously unrecognized influenza B virus glycoprotein form a bicistronic mRNA that also encodes the viral neuraminidase Proc Natl Acad Sci USA 80 4879–4883 Occurrence Handle6308656 Occurrence Handle1:CAS:528:DyaL3sXlslSntbc%3D Occurrence Handle10.1073/pnas.80.16.4879
MW Shaw X Xu YL Susan S Normand R Ueki GY Kunimoto H Hall A Klimov NJ Cox K Subbarao (2002) ArticleTitleReappearance and global spread of variants of influenza B/Victoria/2/87 lineage viruses in the 2000–2001 and 2001–2002 seasons Virology 303 1–8 Occurrence Handle12482653 Occurrence Handle1:CAS:528:DC%2BD38Xps1SjtL8%3D Occurrence Handle10.1006/viro.2002.1719
NA Sundstrom LS Premkumar A Premkumar G Ewart GB Cox PW Gage (1996) ArticleTitleIon channels formed by NB, an influenza B virus protein J Membrane Biol 150 127–132 Occurrence Handle10.1007/s002329900037
InstitutionalAuthorNameWorld Health Organization (2002) ArticleTitleRecommended composition of influenza virus vaccine for use in the 2002–2003 influenza season Wkly Epidemiol Rec 77 57–68
InstitutionalAuthorNameWorld Health Organization (2003) ArticleTitleRecommended composition of influenza virus vaccine for use in the 2003–2004 influenza season Wkly Epidemiol Rec 77 341–348
World Health Organization (2006) WHO consultation on the composition of influenza vaccine for the northern hemisphere 2006–2007. February 13–14, Geneva, Swithzerland. Available at: www.who.int/crs/disease/influenza/vaccinesnorth2006_7/en/
M Yamashita M Krystal WM Fitch P Palese (1988) ArticleTitleInfluenza B virus evolution: co-circulating lineages and comparison of evolutionary pattern with those of influenza A and C viruses Virology 163 112–122 Occurrence Handle3267218 Occurrence Handle1:CAS:528:DyaL1cXlt1ehu78%3D Occurrence Handle10.1016/0042-6822(88)90238-3
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Daum, L., Canas, L., Klimov, A. et al. Molecular analysis of isolates from influenza B outbreaks in the U.S. and Nepal, 2005. Arch Virol 151, 1863–1874 (2006). https://doi.org/10.1007/s00705-006-0777-0
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DOI: https://doi.org/10.1007/s00705-006-0777-0