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Particles and microfluidics merged: perspectives of highly sensitive diagnostic detection

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Abstract

There is a growing need for diagnostic technologies that provide laboratories with solutions that improve quality, enhance laboratory system productivity, and provide accurate detection of a broad range of infectious diseases and cancers. Recent advances in micro- and nanoscience and engineering, in particular in the areas of particles and microfluidic technologies, have advanced the “lab-on-a-chip” concept towards the development of a new generation of point-of-care diagnostic devices that could significantly enhance test sensitivity and speed. In this review, we will discuss many of the recent advances in microfluidics and particle technologies with an eye towards merging these two technologies for application in medical diagnostics. Although the potential diagnostic applications are virtually unlimited, the most important applications are foreseen in the areas of biomarker research, cancer diagnosis, and detection of infectious microorganisms.

There is a growing need for diagnostic technologies that provide laboratories with solutions that improve quality, enhance laboratory system productivity, and provide accurate detection of a broad range of infectious diseases and cancers. In this review, we will discuss many of the recent advances in microfluidics and particle technologies with an eye towards merging these two technologies for application in medical diagnostics such as microfluidic device to monitor molecular secretions in real-time as demonstrated in this figure.

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Authors and Affiliations

  1. Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and the Shriners Hospitals for Children, 51 Blossom St., Boston, 02114, MA, USA

    Tania Konry, Shyam Sundhar Bale, Abhinav Bhushan, Keyue Shen & Martin Yarmush

  2. Department of Electrical and Computer Engineering, University of California, Davis, 3177 Kemper Hall, Davis, CA, 95616, USA

    Erkin Seker

  3. Department of Surgery, Drexel University College of Medicine, Philadelphia, PA, 19102, USA

    Boris Polyak

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  1. Tania Konry
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  2. Shyam Sundhar Bale
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  3. Abhinav Bhushan
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  4. Keyue Shen
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  5. Erkin Seker
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  6. Boris Polyak
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  7. Martin Yarmush
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Correspondence to Tania Konry or Martin Yarmush.

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Konry, T., Bale, S.S., Bhushan, A. et al. Particles and microfluidics merged: perspectives of highly sensitive diagnostic detection. Microchim Acta 176, 251–269 (2012). https://doi.org/10.1007/s00604-011-0705-1

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  • DOI: https://doi.org/10.1007/s00604-011-0705-1

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