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Characterization of sub-systems of a molecular biowire-based biosensor device

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Abstract.

We describe the fabrication and characterization of components of a biosensor system that can be used for simultaneous screening of multiple pathogens in a sample. The two sub-systems are: (1) a mixed antibody immunosensor based on molecular biowires and (2) a multi-channel potentiostat for measuring conductance across the immunosensor. The immunosensor operates by converting binding events between antigen and antibody into a measurable electrical signal using polyaniline nanowires as labels and transducers. By mixing and patterning antibodies on a substrate, the response of the biosensor can detect the presence of either one of several pathogens present in the analyte through an equivalent change in conductance. The paper also presents a 42-channel potentiostat array which can be used for measuring the conductance change across the immunosensor. Each channel of the array uses a novel semi-synchronous ΣΔ modulator which enables detection down to femtoampere current ranges.

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Authors and Affiliations

  1. Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI, USA

    Yang Liu, Amit Gore & Shantanu Chakrabartty

  2. Department of Biosystems Engineering, Michigan State University, East Lansing, MI, USA

    Evangelyn C. Alocilja

Authors
  1. Yang Liu
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  2. Amit Gore
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  3. Shantanu Chakrabartty
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  4. Evangelyn C. Alocilja
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Corresponding author

Correspondence to Yang Liu.

Additional information

Correspondence: Yang Liu, Michigan State University, Department of Electrical and Computer Engineering, East Lansing, MI 48824, USA

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Liu, Y., Gore, A., Chakrabartty, S. et al. Characterization of sub-systems of a molecular biowire-based biosensor device. Microchim Acta 163, 49–56 (2008). https://doi.org/10.1007/s00604-008-0950-0

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  • DOI: https://doi.org/10.1007/s00604-008-0950-0

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