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Development of gelatin flakes, a new type of anti-adhesive material: a preliminary study of in vivo rat adhesion models

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Abstract

To overcome the problems associated with sheet- or film-type anti-adhesive materials, we developed a new type of anti-adhesive material, gelatin flakes. We made two types of gelatin flakes with or without thermal cross-linking, and preliminarily examined their basic properties and the anti-adhesive efficacy using a rodent adhesion model. Both types of the gelatin flakes rapidly turned into gel and tightly attached the injured surfaces, absorbing the moisture and blood, when applied onto the abraded sites of rats. In addition, these flakes could be sprayed into the desired area by compressed air through a device with a long, thin tube, which could be used in laparoscopic surgery. The anti-adhesive effects of both types of gelatin flakes were similar, and both types were significantly superior compared to the non-treated group. Although further investigations are necessary, the gelatin flakes have unique and useful properties and satisfactory anti-adhesive effects, which indicate that they may be applicable in laparoscopic surgery.

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Conflict of interest

None of the authors has any conflicts of interest to declare.

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Authors and Affiliations

  1. Division of Medical Life System, Department of Life and Medical Science, Doshisha University, 1-3 Tatara-Miyakodani, Kyotanabe, Kyoto, 610-0321, Japan

    Hiroyuki Tsujimoto, Hideki Takamori, Misaki Tsuji, Maho Hayashi, Junki Ikeda, Taichi Orikasa, Hiroko Torii, Yuki Ozamoto & Akeo Hagiwara

  2. Research and Development Department, Gunze Ltd., Ayabe, Kyoto, Japan

    Hideki Takamori, Shuko Suzuki, Shinichiro Morita & Yoshito Ikada

Authors
  1. Hiroyuki Tsujimoto
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  2. Hideki Takamori
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  3. Misaki Tsuji
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  4. Maho Hayashi
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  5. Junki Ikeda
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  6. Taichi Orikasa
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  7. Hiroko Torii
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  8. Yuki Ozamoto
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  9. Shuko Suzuki
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  10. Shinichiro Morita
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  11. Yoshito Ikada
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  12. Akeo Hagiwara
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Corresponding author

Correspondence to Hiroyuki Tsujimoto.

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Tsujimoto, H., Takamori, H., Tsuji, M. et al. Development of gelatin flakes, a new type of anti-adhesive material: a preliminary study of in vivo rat adhesion models. Surg Today 44, 391–394 (2014). https://doi.org/10.1007/s00595-013-0608-3

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  • DOI: https://doi.org/10.1007/s00595-013-0608-3

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