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Mating worms and the cystic kidney: Caenorhabditis elegans as a model for renal disease

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Abstract

Polycystic kidney disease (PKD) is caused by a group of variably inherited human disorders that are major causes of end-stage renal disease in both children and adults. The genetic culprits responsible for autosomal-dominant PKD (ADPKD), the polycystins, have been identified, yet still little is known about the molecular mechanisms that result in the disease phenotype. Polycystin homologs have been isolated in the model genetic organism Caenorhabditis elegans and, interestingly, play a specific role in C. elegans male mating behavior. Despite the recruitment of the polycystins for divergent functions in worms and humans it appears that the fundamental molecular and genetic interactions of these genes are evolutionarily conserved. In addition, studies in the worm have contributed to an understanding of the emerging role for cilia in the function of the polycystin pathway, expanding a promising frontier in PKD research. C. elegans has also been used to identify a gene family which may have significance for understanding the formation and maintenance of renal tubules.

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Acknowledgements

I am indebted to Drs. Frederick Kaskel, Gabriel Haddad, Alex Lesokhin, William Gomes, and Galina Kofman for critically reading and reviewing the manuscript.

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  1. Department of Pediatrics, Children’s Hospital at Montefiore, 3415 Bainbridge Avenue, New York, NY, 10467, USA

    Jonathan Lipton

  2. Department of Neurology, Childrens’s Hospital, Boston, Harvard Medical School, 300 Longwood Avenue, Fegan II, Boston, MA, 02115, USA

    Jonathan Lipton

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Correspondence to Jonathan Lipton.

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Lipton, J. Mating worms and the cystic kidney: Caenorhabditis elegans as a model for renal disease. Pediatr Nephrol 20, 1531–1536 (2005). https://doi.org/10.1007/s00467-005-1958-x

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  • DOI: https://doi.org/10.1007/s00467-005-1958-x

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