Abstract.
Pax genes are expressed in specific patterns in the nervous system during development and in the adult. Recent findings suggest a link between the expression of Pax-2 and axonal guidance. Mice with a targeted deletion of Pax-2 are an excellent tool for studying axonal pathfinding at the molecular level, especially with respect to the optic chiasm. The date reviewed here suggest that Pax-2 regulates the expression of surface molecules involved in contact attraction and that the mutual regulation of the expression of Pax-2 and the Sonic hedgehog gene is of importance in the formation of the chiasm region.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received: 30 April 1997 / Accepted: 27 May 1997
Rights and permissions
About this article
Cite this article
Alvarez-Bolado, G., Schwarz, M. & Gruss, P. Pax-2 in the chiasm. Cell Tissue Res 290, 197–200 (1997). https://doi.org/10.1007/s004410050923
Issue Date:
DOI: https://doi.org/10.1007/s004410050923