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Activation of subventricular zone stem cells after neuronal injury

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Abstract

The mammalian subventricular zone (SVZ) has garnered a tremendous amount of attention as a potential source of replacement cells for neuronal injury. This zone is highly neurogenic, harbours stem cells and supports long-distance migration. The general pattern of activation includes increased proliferation, neurogenesis and emigration towards the injury. Intrinsic transcription factors and environmental signalling molecules are rapidly being discovered that may facilitate the induction of these cells to mount appropriate therapeutic responses. The extent of SVZ neurogenesis in humans is controversial. However, tantalizing new data suggest that humans are capable of generating increased numbers of neurons after a variety of diseases.

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  1. Department of Physiology, Anatomy and Genetics, University of Oxford, Le Gros Clark Building, South Parks Road, Oxford, OX1 3QX, UK

    Yongsoo Kim & Francis G. Szele

  2. Institute of Neuroscience, Northwestern University, Evanston, USA

    Yongsoo Kim

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  1. Yongsoo Kim
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  2. Francis G. Szele
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Correspondence to Francis G. Szele.

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F.G.S. was supported by NIH grant NS-42253.

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Kim, Y., Szele, F.G. Activation of subventricular zone stem cells after neuronal injury. Cell Tissue Res 331, 337–345 (2008). https://doi.org/10.1007/s00441-007-0451-1

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