Skip to main content
SpringerLink
Log in

Matrix Gla protein and osteopontin genetic associations with coronary artery calcification and bone density: the CARDIA study

  • Short Report
  • Published:
Human Genetics Aims and scope Submit manuscript

Abstract

A role for matrix proteins has previously been proposed in the pathogenesis of arterial calcification in the setting of atherosclerosis, and a link has been suggested between osteoporosis and arterial calcification. Our aim has been to investigate whether matrix Gla protein (MGP) T-138C, osteopontin (SPP1) T-443C, and Asp94Asp single nucleotide polymorphisms are associated with the development of arterial calcification and bone density. The individual effects of the MGP and SPP1 polymorphisms with coronary calcification are weak and not statistically significant. Bone mineral density differences at both the hip and spine do not vary statistically by genotype for any of the polymorphisms studied. Given the significant role of both MGP and SPP1 in arteriosclerosis, further research in higher risk, older populations are needed to determine fully the way in which MGP and SPP1 polymorphisms are associated with disease.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  • Canfield AE, Farrington C, Dziobon MD, Boot-Handford RP, Heagerty AM, Kumar SN, Roberts IS (2002) The involvement of matrix glycoproteins in vascular calcification and fibrosis: an immunohistochemical study. J Pathol 196:228–234

    Google Scholar 

  • Carr JJ, Nelson JC, Wong NA, McNitt-Gray M, Arad Y, Jacobs DR Jr, Sidney S, Bild DE, Williams OD, Detrano R (2005) Calcified coronary artery plaque measurement with cardiac CT in population-based studies: the standardized protocol of the Multi-Ethnic study of atherosclerosis (MESA) and Coronary Artery Risk Development in Young Adults (CARDIA) study. Radiology 234:35--43

    Google Scholar 

  • Dhore CR, Cleutjens JP, Lutgens E, Cleutjens KB, Geusens PP, Kitslaar PJ, Tordoir JH, Spronk HM, Vermeer C, Daemen MJ (2001) Differential expression of bone matrix regulatory proteins in human atherosclerotic plaques. Arterioscler Thromb Vasc Biol 21:1998–2003

    Google Scholar 

  • Doherty TM, Fitzpatrick LA, Inoue D, Qiao JH, Fishbein MC, Detrano RC, Shah PK, Rajavashisth TB (2004) Molecular, endocrine, and genetic mechanisms of arterial calcification. Endocr Rev 25:629–672

    Google Scholar 

  • Friedman GD, Cutter GR, Donahue RP, Hughes GH, Hulley SB, Jacobs DR Jr, Liu K, Savage PJ (1988) CARDIA: study design, recruitment, and some characteristics of the examined subjects. J Clin Epidemiol 41:1105–1116

    Google Scholar 

  • Giacopelli F, Marciano R, Pistorio A, Catarsi P, Canini S, Karsenty G, Ravazzolo R (2004) Polymorphisms in the osteopontin promoter affect its transcriptional activity. Physiol Genomics 20:87–96

    Google Scholar 

  • Jono S, Ikari Y, Vermeer C, Dissel P, Hasegawa K, Shioi A, Taniwaki H, Kizu A, Nishizawa Y, Saito S (2004) Matrix Gla protein is associated with coronary artery calcification as assessed by electron-beam computed tomography. Thromb Haemost 91:790–794

    Google Scholar 

  • Luo G, Ducy P, McKee MD, Pinero GJ, Loyer E, Behringer RR, Karsenty G (1997) Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. Nature 386:78–81

    Article  CAS  PubMed  Google Scholar 

  • Speer MY, McKee MD, Guldberg RE, Liaw L, Yang HY, Tung E, Karsenty G, Giachelli CM (2002) Inactivation of the osteopontin gene enhances vascular calcification of matrix Gla protein-deficient mice: evidence for osteopontin as an inducible inhibitor of vascular calcification in vivo. J Exp Med 196:1047–1055

    Article  Google Scholar 

  • Taylor BC (2004) Genetic factors in bone density, fracture risk and arterial calcification: an epidemiological investigation using the study of osteoporotic fractures (SOF) and the coronary artery risk development in young adults (CARDIA) study. Dissertation Abstracts International 65:2899B (UMI no. AAT 3137149)

    Google Scholar 

Download references

Acknowledgements

This work was partially supported by contracts N01-HC-48047, N01-HC-48048, N01-HC-48049, N01-HC-48050, and N01-HC-95095 from the National Heart, Lung and Blood Institute. T.M.D. was supported by a grant from Philip Morris USA.

Author information

Authors and Affiliations

  1. Center for Chronic Disease Outcomes Research, VA Medical Center (152/2E), One Veterans Drive, Minneapolis, MN 55417, USA

    Brent C. Taylor

  2. Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minn., USA

    Brent C. Taylor & Pamela J. Schreiner

  3. Burns and Allen Research Institute, Department of Medicine, Cedars-Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, Calif., USA

    Terence M. Doherty

  4. Institute of Molecular Medicine, University of Texas Health Science Center, Houston, Tex., USA

    Myriam Fornage

  5. Department of Radiology, Wake Forest University, Winston-Salem, N.C., USA

    J. Jeffrey Carr

  6. Division of Research, Kaiser Permanente Medical Care Program, Oakland, Calif., USA

    Steve Sidney

Authors
  1. Brent C. Taylor
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Pamela J. Schreiner
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Terence M. Doherty
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Myriam Fornage
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. J. Jeffrey Carr
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Steve Sidney
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Brent C. Taylor.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Taylor, B.C., Schreiner, P.J., Doherty, T.M. et al. Matrix Gla protein and osteopontin genetic associations with coronary artery calcification and bone density: the CARDIA study. Hum Genet 116, 525–528 (2005). https://doi.org/10.1007/s00439-005-1258-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00439-005-1258-3

Keywords

Search

Navigation