Abstract
The midbrain dopamine system via the dorsal and ventral striatum regulates a wide range of behaviors. To dissect the role of dopaminergic projections to the dorsal striatum (nigrostriatal projection) and ventral striatum (mesolimbic projection) in sleep–wake behavior, we selectively chemogenetically stimulated nigrostriatal or mesolimbic projections and examined the resulting effects on sleep in rats. Stimulation of nigrostriatal pathways increased sleep and EEG delta power, while stimulation of mesolimbic pathways decreased sleep and reduced cortical EEG power. These results indicate that midbrain dopamine signaling in the dorsal or ventral striatum promotes sleep or wake, respectively.
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Acknowledgements
This work was supported by National Natural Science Foundation of China 31171049 and 81771430 (M. H. Q.), the Scientific Research Foundation for Returned Overseas Chinese Scholars, State Education Ministry (M. H. Q.), and NIH NS061841 and NS095986 (J. L.).
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Qiu, MH., Zhong, ZG., Chen, M.C. et al. Nigrostriatal and mesolimbic control of sleep–wake behavior in rat. Brain Struct Funct 224, 2525–2535 (2019). https://doi.org/10.1007/s00429-019-01921-w
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DOI: https://doi.org/10.1007/s00429-019-01921-w