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Physiological carbon dioxide, bicarbonate, and pH sensing

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Abstract

In biological systems, carbon dioxide exists in equilibrium with bicarbonate and protons. The individual components of this equilibrium (i.e., CO2, HCO −3 , and H+), which must be sensed to be able to maintain cellular and organismal pH, also function as signals to modulate multiple physiological functions. Yet, the molecular sensors for CO2/HCO −3 /pH remained unknown until recently. Here, we review recent progress in delineating molecular and cellular mechanisms for sensing CO2, HCO −3 , and pH.

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Notes

  1. In this case, it is not known whether the mechanism relies on the presence of a carbonic anhydrase.

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Acknowledgements

We thank Dr. Carsten Wagner (University of Zurich, Switzerland) for the insightful comments on the manuscript.

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  1. Department of Pharmacology, Weill Cornell Medical College, Cornell University, New York, USA

    Martin Tresguerres, Jochen Buck & Lonny R. Levin

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  1. Martin Tresguerres
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Tresguerres, M., Buck, J. & Levin, L.R. Physiological carbon dioxide, bicarbonate, and pH sensing. Pflugers Arch - Eur J Physiol 460, 953–964 (2010). https://doi.org/10.1007/s00424-010-0865-6

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